Antibody and antibody derivative immunoreagents reactive with a

Details Antibody and antibody derivative immunoreagents reactive with a Antibody and antibody derivative immunoreagents reactive with a

1991-05-16

1998-08-25

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

53038815, 53038835, C12N 512, C07K 1610

Patent

active

057982511

ABSTRACT:
The invention features immunoreagents which neutralize the Human Immunodeficiency Virus Type 1 (HIV-1) by binding to a novel conserved epitope of the HIV-1 gp120. These immunoreagents exhibit a broad neutralizing effect upon HIV attachment to host cells, and are therefore useful in the detection, of HIV disease, primarily AIDS (Acquired Immunodeficiency Syndrome) and ARC (AIDS Related Complex). More particularly, the invention relates to novel human monoclonal antibodies selectively reactive to a conserved conformation dependent determinant of the HIV-1 gp120, derivatives thereof, cell lines that produce these antibodies, and the use of the monoclonal antibodies and their derivatives for the detection, prevention, amelioration and treatment of HIV related disease.

REFERENCES:
patent: 4536479 (1985-08-01), Vander-Malie
patent: 5215913 (1993-06-01), Posner
Fahey et al. Clin Exp Immunol. 88:1-5, 1992.
Robinson et al. AIDS Res Human Retroviruses 6:567-79, May 1990.
Haigwood et al., Vaccines 90 CSHL Press, Mar. 5, 1990 pp. 33-317.
Chou et al. J. Inf. Diseases 157:805-811, 1988.
Better et al. Mtds in Enzymology 178:476-96, 1989.
Gorny et al. PNAS USA 86:1624-28, Mar. 1989.
Kipps et al. Handbook of Exptl. Immunol. vol. IV Blackwell Scientific Publ. eir et al Eds. 1986 pp. 108.1-108.8.
Goding "Monoclonal Antibodies: Principals and Practice" Academic Press 1983, pp. 118-123.
Morrison, Science 229: 1202-1207, 1985.
Posner et al. J. Immunology 146:4325-4332, 1991.
Kozbor et al., Immunology 4:72-79, 1989.

Affiliated with

Also associated with

Rating

Antibody and antibody derivative immunoreagents reactive with a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibody and antibody derivative immunoreagents reactive with a , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibody and antibody derivative immunoreagents reactive with a will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-35676