Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-07-04
2006-07-04
Murphy, Joseph (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388220, C530S388230, C530S389100, C530S391100, C530S391300
Reexamination Certificate
active
07071310
ABSTRACT:
The present invention relates to an antibody capable of binding to human TLR2 and which (i) binds only to CD14+cells in a normal human mononuclear cell population, and not to CD14−cells; (ii) does not inhibit LPS-induced activation of normal human mononuclear cells, and to the uses thereof, for example in the treatment of bacterial infections which are mediated via the TLR2 receptor, especially bacterial sepsis. In a particular embodiment of this aspects, a utility in the treatment ofListeriainfections is proposed. The antibodies also have a utility as a general research tool, for example in screening for TLR2 expression, and in the study of TLR2 function. A further aspect of the invention provides use of an agent capable of inhibiting TLR2 activation in the preparation of a composition for the treatment ofListeriainfections.
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Espevik Terje
Sundan Anders
Dorsey & Whitney LLP
Hamud Fozia
Leiv Eiriksson Nyskaping AS
Murphy Joseph
LandOfFree
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