Antibody against rheumatoid arthritis specific protein

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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530388, 530395, 530806, 530808, 43524027, 424 858, A61K 39395, C07K 1528, C12N 500

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active

049507419

ABSTRACT:
A substantially pure rheumatoid arthritis specific protein (RASP) and an antibody against the rheumatoid arthritis specific protein (anti-RASP antibody) are disclosed. The RASP is found specifically in the serum or plasma of a patient suffering from rheumatoid arthritis, and may be detected using an anti-RASP antibody easily and effectively. Therefore, the anti-RASP antibody of the present invention is useful for the diagnosis of rheumatoid arthritis by the criterion of the presence of RASP.

REFERENCES:
patent: 4420461 (1983-12-01), Reckel et al.
patent: 4544640 (1985-10-01), Soma et al.
T. Kanamono et al., "An Experience of Plasma Exchange for Patients with Rheumatoid Arthritis", pp. 280-286 (Ref. 1).
T. Kanamono et al., "Analysis of Plasma Filtrated Protein and Finding of New Rheumatoid Arthritis Specific Protein", p. 20 (Ref. 2).
O. Oda et al., "Seikagaku (Biochemistry)", vol. 55, No. 8, p. 767 (1983) (Ref. 3).
H. Yamaga et al., "Abnormal Plasma Protein in the Patients with Rheumatoid Arthritis", Jun. 22-24, 1984 (Ref. 4).
Fong et al., J. Immunol., 131(2), 719-723, 1983 (Aug.).

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