Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1998-06-26
2000-12-05
Ungar, Susan
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303871, 5303882, 53038822, 5303911, 5303913, 435326, C12N 964, C07K 1600
Patent
active
061568821
ABSTRACT:
The invention relates to a monoclonal antibody specifically binding to the human FLT3/FLK2 receptor protein. The invention further relates to hybridoma cells producing such an antibody, as well as to a method for generation of such hybridoma cells. The monoclonal antibody is the antibody produced and released by hybridoma cells deposited under No. DSM 2249 at the German Collection of Microorganisms and Cell Cultures (DSMZ) and designated as 4G8B4B12.
REFERENCES:
Rappold I. et al., "Epitope Recognition, Functional Aspects, and Reactivity of Anti-FLT3-FLK2 Antibodies", Tissue Antigens, vol. 48 No. 4-2 (1996) p. 399 (XP002080668).
Rosnet O. et al., "Human FLT3/FLK2 Receptor Tyrosine Kinase is Expressed at the Surface of Normal and Malignant Hemotopoietic Cells", Leukemia, vol. 10 No. 2, (1996) pp. 238-248 (XP002080669).
Goldstein, N. "71E1, Anti-FLK-2 Tyrosine Kinase Receptor", Hybridoma, vol. 14 No. 5, (1995) p. 513 (XP002080670).
Rose, C. et al., "Isolation and Characterization of a Monoclonal Antibody Binding to the Extracellular Domain of the FLK-2 Tyrosine Kinase Receptor", Hybridoma, vol. 14 No. 5, (1995) pp. 453-459 (XP002080671).
Rappold I. et al., "Functional and Phenotypic Characterization of Cord Blood and Bone Marrow Subsets Expressing FLT3 (CD135) Receptor Tyrosine Kinase", Blood, vol. 90 No. 1, (1997) pp. 111-125 (XP002080672).
Kimmel et al (J. Neurosurg, 66:161-171), 1987.
Hird et al (in "Genes and Cancer", Carney et al., Eds., John Wiley and Sons Ltd, 83-89), 1990.
Freshney (Culture of Animal Cells, A Manual of Basic Tecnique, Alan R. Liss, Inc., New York, p. 4), 1983.
Dermer (Bio/Tchnology, 12:320), 1994.
Buhring Hans-Jorg
Rappold Irene
Eberhard-Karls-Universitat Tubingen
Hamrick Claude A. S.
Ungar Susan
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