Antibodies with specificity for a common epitope on E-selectin a

Details Antibodies with specificity for a common epitope on E-selectin a Antibodies with specificity for a common epitope on E-selectin a

1995-06-05

1998-05-26

Feisee, Lila

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241431, 4241521, 4241531, 4241541, 4241721, 4241731, 435 71, 435 72, 435 711, 435 724, 435 7021, 4351722, 5303882, 53038822, 53038873, 53038875, 5303896, A61K 39395, C07K 1628, G01N 3353

Patent

active

057560951

ABSTRACT:
The present invention involves monoclonal antibodies which recognize a common determinant found on separate and distinct adhesion molecules. The monoclonal antibodies are used for blocking cellular adhesion. Monoclonal antibodies are also described that are capable of binding to a common determinant expressed on separate and distinct selectins and in particular antibodies that bind to both E-selectin (also known as ELAM-1) and L-selectin (also known as LAM-I, LECAM-1, Leu-8, TQ-1, gp 90 MEL-14 and peripheral lymph node homing receptor). The monoclonal antibodies are useful in the diagnosis, treatment and prevention of diseases associated with inflammation. The monoclonal antibodies are used for detecting cells bearing selectins. Cell lines capable of producing the above described antibodies are also described.

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