Antibodies with binding affinity for the CD3 antigen

Details Antibodies with binding affinity for the CD3 antigen Antibodies with binding affinity for the CD3 antigen

1994-12-23

1999-10-19

Budens, Robert D.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

4241421, 4241541, 5303873, 53038875, A61K 39395, C07K 1628

Patent

active

059685093

ABSTRACT:
An antibody or antibody fragment with a binding affinity for the CD3 antigen, having a human constant region, and human or rat variable framework region, a heavy chain with CDRs having the amino acid sequences:

REFERENCES:
patent: 5225539 (1993-07-01), Winter
Routledge et al. "A humanized monovalent CD3 antibody . . . " Eur. J. Immunol. 21 (1991) pp. 2649-2898.
Clark et al. "The Improved lytic function . . . " Euro. Jour. Immunol. 1989, 19: 381-388.
Rudikoff et al. "Single amino acid . . . " Proc. Natl Acad. of Sci. USA 79:1979-1983. Mar. 1982.
Riechmann et al. "Reshaping human antibodies . . . " Nature 332: 323-377, Mar. 24, 1988.
Verhoeyen et al. "Reshaping human antibodies . . . " Science 239:1534-1536, Mar. 25, 1988.
Queen et al. "A humanized antibody . . . " Proc. Natl Aca. Sci. USA, 86:10029-10033, Dec. 1989.
Cobbold et al. "Therapeutic potential of . . . " Nature 308:460-462, Mar. 29, 1984.
Osband et al. "Problems on the investigational study . . . " Immunology Today 11(6):193-195, 1990.
Waldmann "Monoclonal antibodies in diagnosis and therapy" Science, vol. 252:1657-1662, Jun. 21, 1991.
Dillman, R.O. "Monoclonal antibodies for treating cancer" Annals of Internal Medicine 1989 111:592-603.
Hird et al. "Immunotherapy with monoclonal antibodies" Genes and Cancer, pp. 183-189. Carey et al. Eds. Wiley & Sons Ltd. 1990.

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