Antibodies which specifically bind to a novel .kappa./.mu.-like

Details Antibodies which specifically bind to a novel .kappa./.mu.-like Antibodies which specifically bind to a novel .kappa./.mu.-like

1997-12-16

2000-07-04

Duffy, Patricia A.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Animal cell, per se, expressing immunoglobulin, antibody, or...

435331, 435334, 5303881, 53038822, 53038826, C07K 1600, C12N 512

Patent

active

060837489

ABSTRACT:
The present invention is directed to antibodies which specifically bind to a novel .kappa./.mu.-like protein tyrosine phosphatase protein herein designated PTP .lambda. and hybridoma cell lines producing the same.

REFERENCES:
Cheng, J., et al., "A Novel Protein-Tyrosine Phosphatase Related to the Homotypically Adhering .kappa. and .mu. Receptors", The Journal of Biological Chemistry, vol. 272, No. 11, pp. 7264-7277 (Mar. 14, 1997).
Maher, Pamela A., "Tissue-dependent Regulation of Protein Tyrosine Kinase Activity during Embryonic Development", The Journal of Cell Biology, vol. 112, No. 5 (Mar. 1991).
Tonks, N.K., "Introduction: Protein Tyrosine Phosphatases," Seminars in Cell Biology, 4:373-377.
Walton, K.M. and J.E. Dixon, "Protein Tyrosine Phosphatases," Annu. Rev. Biochem. 62:101-120.
Sun, H., and N.K. Tonks, "The Coordinated Action of Protein Tyrosine Phosphatases and Kinases i Signaling," TIBS, 19(11):480-485 (1994).
Brady-Kalnay, S.M., and N.K. Tonks, "Protein Tyrosine Phosphatases as Adhesion Receptors," Curr Opinion in Cell Biology, 7:650-657 (1995).
Beckman, G and P. Bork, "An Adhesive Domain Detected in Functionally Diverse Receptors," TIBS, 41 (1993).
Jiang, Y.-P., et al., "Cloning and Characterization or R-PTP-.kappa., a New Member of the Receptor Prot Tyrosine Phosphatase Family with a Proteolytically Cleaved Cellular Adhesion Molecule-Like Extrac Region," Molecular and Cellular Biology, 13(5):2942-2951 (1993).
Gebbink, M.F.B.G., et al., "Cloning, Expression and Chromosomal Localization of a New Putative Receptor-Like Protein Tyrosine Phosphatase," FEBS, 290(1,2):123-130 (1991).
Brady-Kalnay, S.M., et al., "Homophilic Binding of PTP.mu., a Receptor-Type Protein Tyrosine Phosph Can Mediate Cell-Cell Aggregation," J. Cell. Biol., 122(4):961-972 (1993).
Gebbink, M.F.B.G., et al., "Cell-Cell Adhesion Medicated by a Receptor-Like Protein Tyrosine Phosphatase," The Journal of Biological Chemistry, 268(22):16101-16104 (1993).
Sap, J., et al., "Receptor Tyrosine Phosphatase R-PTP-.kappa. Mediates Homophilic Binding," Molecular Cellular Biology, 14(1):1-9 (1994).
Brady-Kalnay, S.N., and N.K. Tonks, "Identification of the Homophilic Binding Site of the Receptor Tyrosine Phosphatase PTP.mu.*," The Journal of Biological Chemistry, 269(45):28472-28477 (1994).
Zondag, G.C.M., "Homophilic Interactions Mediated by Receptor Tyrosine Phosphatases .mu. and .kappa.," Journal of Biological Chemistry, 270(24):14247-14250 (1995).
Brady-Kalnay, S.M., et al., "Receptor Protein Tyrosine Phosphatase PTP.mu. Associates with Cadherin Catenins In Vivo," J. Cell. Biol., 130(4):977-986 (1995).
Fang, K.S., et al., "A Transmembrane Protein-Tyrosine Phosphatase Contains Spectrin-Like Repeat Extracellular Domain," The Journal of Biological Chemistry, 269(19):14056-14063 (1994).
Kaplan, R., et al., "Cloning of Three Human Tyrosine Phosphatases Reveals a Multigene Family of Receptor-Linked Protein-Tyrosine-Phosphatases Expressed in Brain," PNAS USA, 87:7000-7004.
Campbell et al. in Laboratory Techniques in Biochemistry and Molecular Biology, vol. 23 Monoclonal Antibody and Immunosensor Technology, Elsevier, 1991 p. 3.
Goding, et al. "Monoclonal Antibodies: Principles and Practice" Academic Press Inc, Orlando FL, 1983, pp. 56-97.

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