Antibodies which catalyze hydrolysis of ester bonds

Details Antibodies which catalyze hydrolysis of ester bonds Antibodies which catalyze hydrolysis of ester bonds

1987-08-18

1991-07-09

Kepplinger, Esther L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530388, 530391, 435 691, 435 7021, 4351722, 43524027, 435174, 435197, 435212, A61K 39395, C07K 1521

Patent

active

050307177

ABSTRACT:
An analog-ligand having a conformation that substantially corresponds to the conformation of a hydrolytic transition state of an amide or ester reactant ligand is used to produce receptor molecules of predetermined specificity. The receptor molecules include an antibody combining site that binds to a reactant ligand and thereby stabilizes the tetrahedral carbon atom of the amide or ester hydrolysis transition state of that reactant ligand to catalytically hydrolyze the reactant ligand at a predetermined site.

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