Antibodies which bind to insect gut proteins and their use

Details Antibodies which bind to insect gut proteins and their use Antibodies which bind to insect gut proteins and their use

1995-05-16

1997-11-11

Eisenschenk, Frank C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

5303873, 5303881, 5303871, C07H 2104, C07K 1600, C07K 1618, C07K 1646

Patent

active

056866003

ABSTRACT:
Antibodies, monoclonal antibodies or fragments thereof which bind to brush border membrane vesicles of insect gut and the gene or genes which encode these proteins are provided. The monoclonal antibodies bind the gut of a target insect but do not bind to mammalian brush border membranes or to plant microsomes. The antibodies and the genes encoding them find use in constructing hybrid toxins for control of insect pests.

REFERENCES:
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4946778 (1990-08-01), Ladner et al.
patent: 5196320 (1993-03-01), Gillies
patent: 5290914 (1994-03-01), Wilcox et al.
patent: 5306628 (1994-04-01), Sivasubramanian et al.
Batra, J.K., et al., "single-Chain Immunotoxins Directed at the Human Transferrin Receptor Containing Pseudomonas Exotoxim A or Diptheria Toxin; Anti-TFR(Fv)-PE40 and DT388-Anti-TRF(Fv)", Molecular and Cellular Biology, 11(4):2200-2205 (1991).
Brinkmann, U. et al., "B3(Fv)-PE38KDEL, a Single-chain Immunotoxin That Causes Complete Regression of a Human Carcinoma in Mice", PNAS, 88:8616-8620 (1991).
Chaudhary, V.K., et al., "A Recombinant Immunotoxin Consisting of Two Antibody Variable Domains Fused to Pseudomonas Exotoxin", Nature, 339:394-397 (1989).
Chaudhary, V.K., et al., "A Recombinant Single-chain Immunotoxin Composed of Anti-Tac Variable Regions and a Truncated Diphtheria Toxin", PNAS, 87:9491-9494 (1990).
Oddou, P., et al., "Identification and characterization of Heliothis virescens midgut membrane proteins binding Bacillus thuringiensis .delta.-endotoxins", Eur. J. Biochem., 202:673-680 (1991).
Oddou, P., et al., "Immunologically unrelated Heliothis sp. and Spodoptera sp. midgut membrane-proteins bind Bacillus thuringiensis CryIA(b) .delta.-endotoxin", Eur. J. Biochem., 212:145-150 (1993).
Pastan, I. et al., "Recombinant Toxins as Novel Therapeutic Agents", Annu. Rev. Biochem., 61:331-354 (1992).
Federici, B.A., "Insecticidal Bacterial Proteins Identify the Midgut Epithelium as a Source of Novel Target Sites for Insect Control", Archives of Insect Biochemistry and Physiology, 22;357-371 (1993).
Azuma et al., "Discrete Localization of Distinct Alkaline Phosphatase Isozymes in the Cell Surface of Silkworm Midgut Epithelium", The Journal of Experimental Zoology, 251:108-112 (1989).
Crankshaw et al., "Interspecies Cross-Reactivity of an Antibody to Southern Armyworm (Spodoptera eridania) Midgut Nadphcytochrome C Reductase", Insect. Biochem., 11(5):593-597 (1981).
Gutierrez et al., "Antibodies from Chagas Patients Serum Bind to the Gut Epithelial Cell Surface of Triatoma infestans", Micr. Electr. Biol. Cel., 15(2):145-158 (1991).
Hiatt et al., "Monoclonal antibody engineering in plants", FEBS, 307(1):71-75 (1992).
Ryerse et al., "Peritrophic Membrane Structure and Formation in the Larva of a Moth, Heliothis", Tissue and Cell, 24(5):751-771 (1992).
Schots et al., "Plantibodies': a flexible approach to design resistance against pathogens", Neth. J. Pl. Path., 98(2):183-191 (1992).
Tavladoraki et al., "Transgenic plants expressing a functional single-chain Fv antibody are specifically protected from virus attack", Nature, 366:469-472 (1993).

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