Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-07-16
2000-10-24
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
53038822, C07K 1628
Patent
active
061369578
ABSTRACT:
The invention provides a recombinant or synthetic receptor or a derivative thereof, for granulocyte-macrophage colony-stimulating factor (GM-CSF). The GM-CSF receptor is useful, inter alia, in the treatment or diagnosis of GM-CSF-related diseases, and in the screening of agonists and antagonists of GM-CSF receptors. The invention further provides antibodies directed against GM-CSF receptor or derivatives thereof, and pharmaceutical compositions comprising either the GM-CSF receptor, the receptor derivative, or an antibody thereto, and methods of using thereof.
REFERENCES:
patent: 5112961 (1992-05-01), Hayashida et al.
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DiPersio, J.F. et al., "Human Granulocyte-Macrophage Colony-Stimulating Factor and Other Cytokines Prime Human Neutrophils for Enhanced Arachidonic Acid Release and Leukotriene B.sub.4 Synthesis," J. Immunol. 140:4315-4322 (Jun. 1988).
DiPersio, J.F. et al., "Characterization of the Soluble Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor Complex," J. Biol. Chem. 266(1):279-286 (Jan. 1991).
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Gough, N.M. et al., "Localization of the Human GM-CSF Receptor Gene to the X-Y Pseudoautosomal Region," Nature 345:734-736 (Jun. 1990).
Lewin, R., "When Does Homology Mean Something Else?" Science 237:1570 (Sep. 1987).
Metcalf, D. et al., "Low-Affinity Placenta-Derived Receptors for Human Granulocyte-Macrophage Colony-Stimulating Factor Can Deliver a Proliferative Signal to Murine Hemopoietic Cells" Proc. Natl. Acad. Sci. USA 87:4670-4674 (Jun. 1990).
Raines, J.A. et al., "Identification anad Molecular Cloning of a Soluble Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor," Proc. Natl. Acad. Sci. USA 88:8203-8207 (Sep. 1991).
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Gearing David Paul
Gough Nicholas Martin
King Julie Ann
Metcalf Donald
Nicola Nicos Anthony
Amrad Corporation Limited
Ulm John
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