Antibodies to VPF

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using tissue cell culture to make a protein or polypeptide

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435 702, 435 7021, 4351722, 4352402, 43524027, 530387, C12P 2100, C12P 2108

Patent

active

050360035

ABSTRACT:
A method of producing antibodies against vascular permeability factor (VPF) is disclosed which comprises immunizing a host animal with a peptide having an amino acid sequence as follows: ##STR1## or a fragment of said peptide containing an antigenic determinant of VPF.

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Stites et al., Basic & Clinical Immunology, 1984, pp. 22-25.
Senger et al., Canc. Res., 46:5629-5632, 1986, "A Highly Conserved Vascular Permeability Factor Secretely by a Variety of Human & Rodent Tumor Cell Lines".
Kohler et al., Nature, 256:495-497, 1975, "Continuous Cultures of Fused Cells Secreting Antibody of Predetermined Specificity".
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Folkman and Klagsbrun, Science, 235, 442-447 (1987).
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Kadish et al., Tissue & Cell 11, 99 (1979).
Dvorak et al., J. Natl. Cancer Inst. 62, 1459-1472 (1979).
Lobb et al., Int. J. Cancer 36, 473-478 (1985).

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