Antibodies to truncated VEGF-D and uses thereof

Details Antibodies to truncated VEGF-D and uses thereof Antibodies to truncated VEGF-D and uses thereof

2006-08-29

2006-08-29

Chan, Christina (Department: 1644)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S326000, C530S391100, C530S391300, C424S145100, C424S178100

Reexamination Certificate

active

07097986

ABSTRACT:
The invention is based on the isolation of antibodies that were made to a polypeptide having the amino acid sequence for a truncated VEGF-D. One of these antibodies can interfere with the activity of VEGF-D mediated by VEGFR-2 and interfere with the binding of VEGF-D to VEGFR-3 but does not interfere with the activity of VEGF mediated by VEGFR-2 or bind to VEGF-C. The invention provides pharmaceutical and diagnostic compositions and methods utilizing these antibodies.

REFERENCES:
patent: 6342219 (2002-01-01), Thorpe et al.
patent: 98/07832 (1998-02-01), None
Kuby et al., 1994, Immunology, second edition, pp. 85-96.
Abaza et al, J of Protein Chemistry 11(5): 433-444, 1992.
Harlow et al, in Antibodies a Laboratory Manual, 1988, Cold Spring harbor laboratory publication, Cold Spring Harbor, NY, p. 319-329.
Joukov et al, EMBO J 16(13): 3898-3911, 1997.

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