Antibodies to transferrin receptor-like proteins

Details Antibodies to transferrin receptor-like proteins Antibodies to transferrin receptor-like proteins

2007-05-01

2007-05-01

Li, Ruixiang (Department: 1646)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

C424S141100, C530S387100, C530S388100, C530S389100

Reexamination Certificate

active

11448552

ABSTRACT:
The present invention provides isolated nucleic acids encoding TfR2 polypeptides, or fragments thereof, and isolated TfR2 polypeptides encoded thereby. Further provided are vectors containing the nucleic acids of the present invention, host cells transformed therewith, antisense oligonucleotides thereto and compositions containing antibodies that specifically bind to invention polypeptides. Methods of detecting TfR2 protein in a cell are also provided.

REFERENCES:
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Chonn A. et al. Recent advances in liposomal drug-delivery systems. Current opinion in Biotechnology 1995 6:697-708.
Mikayama T. Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor. Proc. Natl. Acad. Sci. USA vol. 90, pp. 10056-10060, 1993.
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Kawabata, H., et al., “Molecular Cloning of Transferrin Receptor 2”,Journal of Biological Chemistry, (Jul. 1999) 20826-32, vol. 274.
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Glockner, G. et al.: “Large-scale sequencing of two regions in human chromosome 7q22: Analysis of . . . ” GENOME Res, vol. 8, Oct. 1998, pp. 1060-1073 table 3, p. 1067, paragraph 1.
Schneider, C. et al.: “Primary structure of human transferrin receptor deduced from the mRNA sequence” NATURE, vol. 311, 1984, pp. 675-678.
Brooks, D. et al.: “Phase Ia trial of murine immunoglobulin A antitransferrin receptor antitransferrin receptor antibody 42/6” Clin. Cancer Res., vol. 1, No. 11, Nov. 1995 pp. 1259-1265.
Nikinmaa, B. et al.: “Monoclonal antibodies to a purified human transferrin receptor” Scand. J. Immunol., vol. 20, No. 5, Nov. 1984 pp. 441-447.
Trinder, D. et al.: “Transferrin Receptor—Independent Uptake of Differic Transferrin by Human Hepatoma Cells With Antisense Inhibition of Receptor Expression” Hepatology, vol. 23, No. 6, Jun. 1996, pp. 1512-1520.
Voet et al.,Biochemistry, 1990, John Wiley & Sons, Inc., pp. 126-128 and 228-234.
Mikayama, T., “Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor,” Proc. Natl. Acad. Sci. USA, vol. 90, pp. 10056-10060, 1993.
Brooks, D. et al.:; “Phase la trial of murine immunoglobulin A antitransferrin receptor antitransferrin receptor antibody 42/6” Clin. Cancer Res., vol. 1, No. 11, Nov. 1995, pp. 1559-1265.
Hillier, LD et al., “Generation and analysis of 280,000 human expressed sequence tags,” Genome Research, vol. 6:807-828, 1996.
Chonn A. et al., “Recent advances in liposomal drug-delivery systems,” Current opinion in Biotechnology 1995 6:698-708.

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