Antibodies to TNF binding protein I

Details Antibodies to TNF binding protein I Antibodies to TNF binding protein I

1990-08-06

1994-10-25

Scheiner, Toni R.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303881, 5303891, 4241431, 4241721, C07K 1500

Patent

active

053590376

ABSTRACT:
Antibodies to TNF Binding Protein I (TBP-I) are provided that can be used in diagnostic assays and as pharmaceutical agents for either inhibiting or mimicking the effects of TNF on cells.

REFERENCES:
Wallach, David. "Cytotoxins (Tumour Necrosis Factor, Lymphotoxin and Others): Molecular and Functional Characteristics and Interactions with Interferons", in: Interferon 7 (Ion Gresser, Ed.), pp. 83-122, Acad. Press Ltd., London: 1986.
Beutler, B. and A. Cerami. "Cachectin: More Than a Tumor Necrosis Factor", in: The New England Journal of Medicine, vol. 316, No. 7, pp. 379-385 (1987).
Tracey, K. J. et al. "Shock and Tissue Injury Induced by Recombinant Human Cachectin", in: Science, vol. 234 (1986): 470-474.
Brockhaus, M. et al. "Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies", Proc. Natl. Acad. Sci. USA, vol. 87, No. 8, Apr. 1990: pp. 3127-3131.
Englemann, H. et al. "Two tumor necrosis factor-binding proteins purified from human urine," J. Biol. Chem. vol. 265, No. 3, Jan. 25, 1990: pp. 1531-1536.
Engelmann et al., J. Biol. Chem. 264: 11974-11980, 1989.
Olsson et al., Eur. J. Haematol. 42:270-275, 1989.
Seckinger et al., J. Biol. Chem 264: 11966-11973, 1989.
Maurer et al., Methods in Enzymology 70: 49-70, 1980.
Sevier et al., Clin Chem 27: 1797-1806, 1981.

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