Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-11-21
2006-11-21
Devi, S. (Department: 1645)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388100, C530S387900, C424S141100, C424S152100, C424S172100, C435S975000
Reexamination Certificate
active
07138502
ABSTRACT:
Antibodies and agents which can bind to the propeptide of the Int1p protein of yeast microorganisms such asCandida albicansare provided which can be useful in methods for treating or preventing infections arising from such microorganisms. Microorganisms expressing the Int1p protein, such asC. albicansandS. cerevisiae, have shown an ability to immunomodulate host cells which allows infections of these microorganisms to thrive and become virulent. The peptide regions involved in the activation of the Int1p protein are isolated and targeted so as to provide a method of disrupting activation and allow for treatment or prevention of infection by microorganisms expressing the int1p protein. In one preferred embodiment of the invention, an antibody or agent which can bind to the propeptide of the Int1p protein fromC. albicansis utilized in methods to prevent or treat infections caused byC. albicansor other microorganisms expressing the Int1p protein.
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Devore-Carter Denise
Hostetter Margaret K.
Devi S.
Schulman B. Aaron
Stites & Harbison PLLC
Yale University
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