Antibodies to the K12 protein

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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Details

C530S387300, C530S388100, C530S388800, C424S130100, C424S133100, C424S139100, C424S141100, C424S156100

Reexamination Certificate

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07022820

ABSTRACT:
The present invention relates, in general, to a cancer-related protein and to a nucleic acid sequence encoding same. In particular, the invention relates to a protein over expressed in certain neoplastic cells, including breast and ovarian cancer cells, to its encoding sequence, and to diagnostic and treatment methodologies based on same.

REFERENCES:
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patent: 0 652 232 (1995-05-01), None
patent: WO 92/13970 (1992-08-01), None
patent: WO 94/00601 (1994-01-01), None
patent: WO 94/00603 (1994-01-01), None
Fundamental Immunology 242 (William E. Paul, M.D. ed., 3d ed. 1993).
Burgess et al, Journal of Cell Biology vol. 111 Nov. 1990 2129-2138.
Lazar et al Molecular and Cellular Biology Mar. 1988 vol. 8 No. 3 1247-1252.
Schwartz et al, Proc Natl Acad Sci USA vol. 84:6408-6411 (1987.
Lin et al Biochemistry USA vol. 14:1559-1563 (1975.
Lee, “The Accumulation of Three Specific Proteins Related to Glucose-Regulated Proteins In a Temperature-Sensitive Hamster Mutant Cell Line K12”, Journal of Cellular Physiology 106:119-125 (1981).
Cole et al, “Cloning and Expression inEscherichia coliK-12 of the Genes for Major Outer Membrane Protein OmpA fromShigella dysenteriae, Enterobacter aerogenes, andSerratia marcescens”, Journal of Bacteriology 149(1):145-150 (1982).
Slentz-Kesler et al, “Identification and Characterization of K12 (SECTM1), a Novel Human Gene That Encodes a Golgi-Associated Protein with Transmembrane and Secreted Isoforms”, Genomics 47:327-340 (1998).

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