Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1998-04-10
1999-07-20
Caputa, Anthony C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303879, 5303881, 53038822, 5303891, C07K 1628
Patent
active
059257407
ABSTRACT:
A novel polypeptide functions as the .beta. chain of an oncostatin M receptor and is thus designated OSM-R.beta.. Heterodimeric receptor proteins comprising OSM-R.beta. and gp130 bind oncostatin M and find use in inhibiting biological activities mediated by oncostatin M.
REFERENCES:
patent: 5073627 (1991-12-01), Curtis et al.
patent: 5106731 (1992-04-01), Salahuddin et al.
patent: 5120535 (1992-06-01), Marquardt et al.
patent: 5262522 (1993-11-01), Gearing et al.
patent: 5785967 (1998-07-01), Gearing et al.
Zarling et al., "Oncostatin M: A growth regulator produced by differentiated histiocytic lymphoma cells", Proc. Natl. Acad. Sci. USA 83:9739-9743, 1986.
Malik et al., "Molecular Cloning, Sequence Analysis, and Functional Expression of a Novel Growth Regulator, Oncostatin M", Mol. Cell. Biol. 9:2847-2953. 1989.
Linsley et al., "Identification and Characterization of Cellular Receptors for the Growth Regulator, Oncostatin M", J. Biol. Chem. 264:4282-4289, 1989.
Liu et al., "Interleukin-6 Signal Transducer gp 130 Mediates Oncostatin M Signaling", J. Biol. Chem. 267:16763-16766, 1992.
Nair et al., "Identification of a Major Growth Factor for AIDS-Kaposi's Sarcoma Cells as Oncostatin M", Science 255:1430-1432, 1992.
Miles et al., "Oncostatin M as a Potent Mitogen for AIDS-Kaposi's Sarcoma-Derived Cells", Science 255:1432o-1434, 1992.
Gearing et al., "The IL-6 Signal Transduce, gp 130: An Oncostatin M ReReceptor and Affinity Converter for the LIF Receptor", Science 255:1434-1437, 1992.
Gearing and Bruce, "Oncostatin M Binds the High-Affinity Leukemia Inhibitory Factor Receptor", The New Biologist 4:61-65, 1992.
Hibi et al., "Molecular Cloning and Exxpression of an IL-6 Signal Transducer, gp 130", Cell 63:1149-1157, 1990.
Gearing et al., "Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp 130", EMBO J. 10:2839-2848. 1991.
Brown et al., "Regulation of IL-6 Expression by Oncostatin M", J. Immunol. 147:2175-2180, 1991.
De Wit et al., "Interleukin-6 concentrations in the serum of patients with AIDS associated Kaposi's sarcoma during treatment with interferon-alpha", J. Int. Med. 229:539-542, 1991.
Gearing et al., "Reconstitution of high affinity leukemia inhibitory factor (LIF) receptors in haemopoietic cells transfected with the cloned human LIF receptor", Ciba Foundation Symposium 167:245-255, 1992.
Thoma et al., "Oncostatin M and Leukemia Inhibitory Factor Trigger Overlapping and Different Signals Through Partially Shared Receptor Complexes", J. Biol. Chem. 269:6215-6222, 1994.
Thoma et al., "Discrimination Between two Types of Receptors for Oncostatin M: Signal Transduction via MAP Kinase", Keystone Symposia, Keystone, CO, Jan.31-Feb. 7, 1993.
Gearing et al., "Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor", Proc. Natl. Acad. Sci. USA 91:1119-1123, 1994.
Bryn et al., "Biological properties of a CD4 immunoadhesin", Nature 344:667-670, 1990.
Ashkenazi et al., "Protection against endotoxic shock by a tumore necrosis factor receptor immunoadhesin", Proc. Natl. Acad. Sci USA 88:10535-10539, 1991.
Bauman et al., "Reconstitution of the Response to Leukemia Inhibitory Factor, Oncostatin M, and Ciliary Neurotrophic Factor in Hepatoma Cells", J. Biol. Chem. 268:8414-8417, 1993.
Cai et al., "Oncostatin M Is An Autocrine Growth Factor in Kaposi's Sarcoma", Amer. J. Path. 145:74-79, 1994.
Takeshita et al., "Cloning of the .gamma. Chain of the Human IL-2 Receptor", Science 257:379-382, 1992.
Park et al., "The LIF/Oncostatin M Receptor System: A Multi-Subunit Cytokine Receptor Family", Abstract and presentation at workshop on Intra-and Extra-Cellular Signalling in Hematopoiesis, Madrid, May 25-27, 1993.
Liu et al., "Interactions Between Oncostatin M and the IL-6 Signal Transducer, gp 130", Cytokine 6 (3):272-278, May 1994.
Cosman David J.
Mosley Bruce
Caputa Anthony C.
Gucker Stephen
Henry Janis C.
Immunex Corporation
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