Antibodies to protein HPMBQ91

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C435S326000, C435S328000, C435S331000, C530S350000

Reexamination Certificate

active

06919433

ABSTRACT:
The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

REFERENCES:
patent: 5536637 (1996-07-01), Jacobs
patent: 5985606 (1999-11-01), Hillman et al.
patent: 6008194 (1999-12-01), Hillman et al.
patent: 0679 716 (1995-11-01), None
patent: 0 892 053 (1999-01-01), None
patent: WO 97/07198 (1997-02-01), None
patent: WO 98/40483 (1998-09-01), None
patent: WO-98/55612 (1998-12-01), None
patent: WO 00/09709 (2000-02-01), None
patent: WO-01/36979 (2001-05-01), None
Lucas et al. (1992), Localization of the Tachkinin Neurokinin B Precursor Peptide in Rat Brain by Immunocytochemistry and in situ Hybridization, Neuroscience 51(2): 317-345.
Cintado et al. (2001), Increase in Neurokinin B Expression and Tachykinin NK3 Receptor-Mediated Response and Expression in the Rat Uterus with Age, J. Pharm. Exp. Ther. 299(3): 934-938.
Lang et al. (1995), Neurochemical characterization of preprotachykinin B(50-79) immunoreactivity in the rat, Regulatory Peptides 57: 183-192.
Lazarus et al. (1988), Assessment of neuromedin B polyclonal antibodies as molecular probes in neural tissue, J. Neuroscience Methods 23: 161-172.
Bonner et al., “A cDNA encoding the precursor of the rat neuropeptide, neurokinin B,”Molec. Brain Res., 2(3):243-249 (1987).
Kako et al., “Cloning and Sequence Analysis of Mouse cDNAs Encoding Preprotachykinin A and B,”Biomed. Res., 14(4):253-259 (1993).
EBI Accession No. AA004764, Hillier et al., “zh89a10.r1 Soares fetal liver spleen 1NFLS S1Homo sapienscDNA clone 428442 5′ similar to SW:TKNK_Bovin P08858 Neurokinin B Precursor, mRNA sequence” (Jul. 25, 1996).
EBI Accession No. T54351, Hillier et al., “ya93h08.s1 Stratagene placenta (#937225)Homo sapienscDNA clone Image:69279 3′similar to SP:TKNK_Bovin P08858 Neurokinin B Precursor, mRNA sequence” (Feb. 28, 1995).
EBI Accession No. R63635, Hillier et al., “yi09f09.r1 Soares placenta Nb2HPHomo sapienscDNA clone Image:138761 5′similar to SP:TKNK_Bovine P08858 Neurokinin B Precursor, mRNA sequence” (May 31, 1995).
EBI Accession No. T58582, Hillier et al., “ya93h08.r1 Stratagene placenta (#937225)Homo sapienscDNA clone Image:69279 5′similar to SP:TKNK_Bovin P08858 Neurokinin B Precursor, mRNA sequence” (Mar. 4, 1995).
EBI Accession No. R62763, Hillier et al., “yi10c09.r1 Soares placenta Nb2HPHomo sapienscDNA clone Image:138832 5′ similar to SP:TKNK_Bovin P08858 Neurokinin B Precursor, mRNA sequence” (May 30, 1995).
Lang et al., “Neurochemical characterization of preprotachykinin B(50-79) immunoreactivity in the rat,”Regulatory Peptides, 57:183-192 (1995).
Geneseq Accession No: Y12863, Duclert et al., “Human 5′ EST secreted protein SEQ ID No:453” (Jun. 21, 1999).
GenBank Accession No: R60718, Hillier et al., “yh02c10.r1Homo sapienscDNA clone 42116 5′” (May 29, 1995).
GenBank Accession No: T30875, Adams et al., “EST24351Homo sapienscDNA 5′ end similar to None” (Jan. 11, 1995).
GenBank Accession No: N30539, Hillier et al., “yx49g02.r1Homo sapienscDNA clone 265106 5′” (Jan. 6, 1996).
GenBank Accession No: H28536, Hillier et al., “y159b11.r1Homo sapienscDNA clone 162525 5′” (Jul. 19, 1995).
GenBank Accession No: H22240, Hillier et al., “y131h11.s1Homo sapienscDNA clone 159909 3′” (Jul. 8, 1995).
GenBank Accession No: H56776, Diatchenko et al., “EST0040 Testis, SubtractedHomo sapienscDNA clone LUDA-ST6, mRNA sequence” (Oct. 4, 1995).
Kotani, H. et al., “Structure and gene organization of bovine neuromedin K precursor,” Proc. Natl. Acad. Sci., USA, 83:7074-7078, (1986).
Kangawa, K. et al., “Neuromedin K: A Novel Mammalian Tachykinin Identified In Porcine Spinal Cord,” Biochemical and Biophysical Research Communications, 114(2):533-540, ((1983).
Nagashima, A. et al., “Cardiovascular roles of tachykinin peptides in the nucleus tractus solitarii of rats,” Brain Reaearch, 487:392-396, (1989).
Roccon, A. et al., “Study of SR 14281, a new potent non-peptide NK3receptor antagonist on cardiovascular responses in conscious guinea-pig,” British Journal of Pharmacology, 118:1095-1102, (1996).
Brownbill, P. et al., “Neurokinin B is a Paracrine Vasodilator in the Human Fetal Placental Circulation,” Journal of Clinical Endocrinology and Metabolism, 88(5):2164-2170, (2003).
Page, N.M. et al., “Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia,” Nature, 405:797-800, (2000).
Swiss-Prot entry Q9UHFO, “TKNK Human,” (2001).
GenBank Accession No: AAA72813, Hostomsky et al., “trypsin inhibitor” (Apr. 27, 1993).
GenBank Accession No: H56777, Diatchenko et al., “EST0041 Testis, SubtractedHomo sapienscDNA clone LUDA-ST2, mRNA sequence” (Oct. 4, 1995).
Barton et al., “Protein Structure Prediction, A Practical Approach,” IRL Press at Oxford Univ. Press, U.K., pp. 31-63 (1996).
George et al., “Current Methods in Sequence Comparison and Analysis,” Macromolecular Sequencing & Synthesis-Selected Methods and Applications, D.H. Schlesinger (Ed.) Alan R. Liss, Inc. New York, pp. 127-149 (1988).
Suzuki et al., An Introduction to Genetic Analysis, 3d Ed., W.H. Freeman and Company, New York, pp. 421-423 (1986).

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