Antibodies to peptides unique to specific keratin proteins

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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5303892, 5303893, 5303881, 53038885, 530357, 435 72, 435 723, 435 792, 435 793, 435 794, 435 795, 436501, 436503, 436519, A61K 3514, C07K 300, C07K 1300, C07K 1500

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053025113

ABSTRACT:
By cloning the gene for particular keratin proteins, it has been possible to determine amino acid sequences of specific keratins. This has made possible selection of sequences which are unique to a given keratin. The production of antibodies that respond to selected sequences provides means of selectively identifying specific keratins. These diagnostic tools provide means of identifying cell source of malignancies.

REFERENCES:
patent: 4366246 (1982-12-01), Riggs et al.
patent: 4722895 (1988-02-01), Yuspa et al.
Roop et al. Proc. Natl. Acad. Sci. (USA) 80:716-720, 1983.
Steinert et al. Nature 302: 794-800, 1983.

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