Antibodies to peptides having NGF-like activity, and use thereof

Details Antibodies to peptides having NGF-like activity, and use thereof Antibodies to peptides having NGF-like activity, and use thereof

1995-05-24

1998-01-27

Feisee, Lila

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435326, 5303879, 53038824, 5303892, C12N 1585, C07K 1600, G01N 3353

Patent

active

057121001

ABSTRACT:
Disclosed are (A) an antibody to a peptide consisting of 8 to 9, or 12 to 14 successive amino acids from a polypeptide having nerve growth factor-like activity, (B) a method for producing the antibody, (C) a cloned hybridoma which produces the antibody, (D) a method for producing the cloned hybridoma, (E) a conjugate of the above mentioned peptide with a carrier protein, and (F) a method for purifying, and a method for detecting and assaying a polypeptide having nerve growth factor-like activity.

REFERENCES:
Sevier et al., Clin Chem., 27:1794-1806, 1981.
Cathnco et al., J. Neurochem. 50:1003-1010, 1988.
Businaro et al. J. Neurosci Res., 6:89-98, 1981.
Kasaian et al. Biofactors 2:99-104, 1989.
Hu et al. Gene 70:57-65, 1988.
Ullrich et al., Nature, 303, 821 (1983).
Hohn et al, Nature, 344, 339 (1990).
Maisonpierre, Science, 247, 1466 (1990).
Rosenthal et al., Neuron, 4, 767 (1990).
Ernfors et al., Proc. Natl. Acad. Sci. USA, 87, 5454 (1990).
Inoue et al., Seikagaku, 61 (9), 1112, 3a-Ah08 (1989).
Onaka et al., Nippon Nogiekagaku Kaishi, 64 (3)) 335, 2Da5 (1990) and English Translation Thereof.

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