Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-02
1999-02-23
Spector, Lorraine
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303877, 5303881, C07K 1618
Patent
active
058745394
ABSTRACT:
Antibodies directed to nuclear matrix proteins (NMP) are provided. Such antibodies are useful markers in diagnosing and monitoring the stage of malignancy of a cell.
REFERENCES:
patent: 4882268 (1989-11-01), Penman et al.
Thomas E. Miller et al., Detection of Nuclear Matrix Proteins in Serum from Cancer Patients, Cancer Research, 52, pp. 422-427, Jan. 15, 1992.
Robert H. Getzenberg et al., Modifications of the Intermediate Filament and Nuclear Matrix Networks by the Extracellular Matrix, Biochemical and Biophysical Research Communications, vol. 179, No. 1, 1991, pp. 340-344.
James F. Cupo, Electrophoretic analysis of nuclear matrix proteins and the potential clinical applications, Journal of Chromatography, 569 (1991) pp. 389-406.
Robert H. Getzenberg et al., Identification of Nuclear Matrix Proteins in the Cancer and Normal Rat Prostate.sup.1, Cancer Research, 51, 6514-6520, Dec. 15, 1991.
Coffey Donald S.
Getzenberg Robert H.
Partin Alan W.
Spector Lorraine
The Johns Hopkins University School of Medicine
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