Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2011-04-26
2011-04-26
Shafer, Shulamith H (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S389100
Reexamination Certificate
active
07932362
ABSTRACT:
Nucleic acids encoding NRIF3 are described. Polypeptides having amino acid sequences of NRIF3 proteins are also provided. A method is also provided for isolating and cloning NRIF3 cDNA. NRIF3 is useful in development/implementation of high throughput screens to identify novel thyroid hormone receptor (TR) and retinoid X receptor (RXR) agonists and antagonists. Methods are also provided for identifying compounds that directly interfere with the interaction of NRIF3 and TR or RXR. Finally, therapies based on modulation of NRIF3 activity are disclosed.
REFERENCES:
patent: 5585463 (1996-12-01), Shattil et al.
patent: 6551795 (2003-04-01), Rubenfield et al.
patent: 6639064 (2003-10-01), Li et al.
patent: 03080640 (2003-10-01), None
Li et al. The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells. Molecular and Cellular Biology. 2004, vol. 24, pp. 3838-3848.
International Search Report for International Patent Application No. PCT/US05/06237, dated Jan. 30, 2006.
Fischer, U et al. “Apoptosis-Based Therapies and Drug Targets.” Cell Death and Differentiation (2005) 12, 942-961.
Freshney, R. Ian. “Culture of Animal Cells: A Manual of Basic Technique.” Alan R. Liss, Inc., 1983, New York: pp. 4.
Dermer, Gerald B. “Another Anniversary for the War on Cancer.” Bio/Technology, Mar. 1994, vol. 12: 320.
Zips. Daniel et al. “New Anticancer Agents: In Vitro and In Vivo Evaluation.” in vivo 19: 1-8 (2005).
Shattil, et al, 1995. “Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit.” The Journal of Cell Biology 131: 807-816.
Bowie, et al, 1990. “Deciphering the message in protein sequences: tolerance to amino acid substitutions.” Science 247(4948): 1306-1310.
Wells, et al, 1990. “Additivity of mutational effects in proteins.” Biochemistry 29: 8509-8517.
Ngo, et al, 1994. The Protein Folding Problem and Tertiary Structure Prediction. Merz, et al, eds. Birkhauser, Boston. pp. 433-506.
Li Dangsheng
Samuels Herbert
Yajnik Vandana
Fish & Richardson P.C.
New York University
Shafer Shulamith H
LandOfFree
Antibodies to NRIF3 proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies to NRIF3 proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies to NRIF3 proteins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2619717