Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-11-21
2006-11-21
Mertz, Prema (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387300, C530S388100, C530S388230, C530S389200
Reexamination Certificate
active
07138498
ABSTRACT:
Human chemokine polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed.
REFERENCES:
patent: 4897348 (1990-01-01), Johnson et al.
patent: 5011912 (1991-04-01), Hopp et al.
patent: 5278287 (1994-01-01), Rollins et al.
patent: 5306709 (1994-04-01), Gewirtz
patent: 5346686 (1994-09-01), Lyle et al.
patent: 5413778 (1995-05-01), Kunkel et al.
patent: 5474983 (1995-12-01), Kuna et al.
patent: 5602008 (1997-02-01), Wilde et al.
patent: 5936068 (1999-08-01), Wilde et al.
patent: 6096300 (2000-08-01), Hromas
patent: 6174995 (2001-01-01), Li et al.
patent: 6673344 (2004-01-01), Li et al.
patent: 0538 030 2 (1993-04-01), None
patent: 07089866 (1995-04-01), None
patent: WO-90/06321 (1990-06-01), None
patent: WO-91/04274 (1991-04-01), None
patent: WO-91/12815 (1991-09-01), None
patent: WO-92/05198 (1992-04-01), None
patent: WO-92/20372 (1992-11-01), None
patent: WO-95/17092 (1995-06-01), None
patent: WO-95/31467 (1995-11-01), None
patent: WO-95/31468 (1995-11-01), None
patent: WO-96/05856 (1996-02-01), None
patent: WO-96/06169 (1996-02-01), None
patent: WO-96/09062 (1996-03-01), None
patent: WO-96/16979 (1996-06-01), None
patent: WO-96/39520 (1996-12-01), None
patent: WO-96/39521 (1996-12-01), None
patent: WO-96/39522 (1996-12-01), None
patent: WO-97/15594 (1997-05-01), None
patent: WO-97/15595 (1997-05-01), None
patent: WO-97/31098 (1997-08-01), None
patent: WO-97/35982 (1997-10-01), None
patent: WO-98/01557 (1998-01-01), None
patent: WO-98/09171 (1998-03-01), None
patent: WO-98/11226 (1998-03-01), None
patent: WO-98/14573 (1998-04-01), None
patent: WO-98/17800 (1998-04-01), None
patent: WO-98/21330 (1998-05-01), None
patent: WO-99/47674 (1999-09-01), None
Adams et al., GenBank Accession No. AA297433 (Apr. 18, 1997).
Hillier et al., GenBank Accession No. AA403048 (May 16, 1997).
Hillier et al., GenBank Accession No. AA404346 (May 16, 1997).
Hillier et al., GenBank Accession No. AA426245 (Oct. 16, 1997).
Marra et al., GenBank Accession No. AA739063 (Jan. 14, 1998).
Garcia-Zepeda et al., GenBank Accession No. AAB38703 (Dec. 16, 1996).
Hromas et al., GenBank Accession No. AAB61534.1 (Aug. 6, 1996).
Rossi et al., GenBank Accession No. AAC50943.1 (Aug. 6, 1996).
Dante et al., GenBank Accession No. AC002482 (Aug. 21, 1997).
Hillier et al., GenBank Accession No. AI735669 (Jun. 14, 1999).
Strausberg, GenBank Accession No. AI925360 (Sep. 2, 1999).
Hein et al., GenBank Accession No. AJ000979 (Jun. 30, 1997).
Bartels et al., GenBank Accession No. AJ001634 (Sep. 10, 1997).
Bartels et al., GenBank Accession No. CAA04888 (Sep. 10, 1996).
Power et al., GenBank Accession No. CAA66950 (Dec. 16, 1997).
Bartels et al., GenBank Accession No. CAB01111 (Jul. 30, 1996).
Bartels et al., GenBank Accession No. CAB01112 (Jul. 30, 1996).
Matoba et al., GenBank Accession No. D17181 (Jun. 21, 1993).
Sudo et al., GenBank Accession No. D31065 (Feb. 8, 1995).
Hieshima et al., GenBank Accession No. D86955 (Mar. 6, 1997).
Wilde et al., GenBank Accession No. I35613 (Feb. 22, 1997).
Choi et al., GenBank Accession No. R29479 (Apr. 25, 1995).
Bell et al., GenBank Accession No. T27336 (Dec. 6, 1994).
Bell et al., GenBank Accession No. T27433 (Dec. 6, 1994).
Hillier et al., GenBank Accession No. T64134 (Feb. 17, 1995).
Hillier et al., GenBank Accession No. T64262 (Feb. 17, 1995).
Garcia-Zepeda et al., GenBank Accession No. U46767 (Dec. 14, 1996).
Hromas et al., GenBank Accession No. U64197 (Jun. 25, 1997).
Rossi et al., GenBank Accession No. U77035 (Jan. 23, 1997).
Hillier et al., GenBank Accession No. W44398 (Jun. 11, 1998).
Marra et al., GenBank Accession No. W57475 (Sep. 7, 1998).
Hillier et al., GenBank Accession No. W61279 (Sep. 24, 1998).
Power et al., GenBank Accession No. X98306 (Jul. 20, 1998).
Bartels et al., GenBank Accession No. Z77650 (Jul. 30, 1996).
Bartels et al., GenBank Accession No. Z77651 (Jul. 30, 1996).
Bandman et al., Geneseq Accession No. AAR95690 (Dec. 20, 1996).
Kreider et al., Geneseq Accession No. AAW17660 (Dec. 16, 1997).
Adams et al., Geneseq Accession No. R93087 (Aug. 27, 1996).
Bandman et al., Geneseq Accession No. R95690 (Dec. 20, 1996).
Godiska et al., Geneseq Accession No. T90880 (May 21, 1998).
Godiska et al., Geneseq Accession No. T90883 (May 21, 1998).
Garcia-Zepeda et al., Geneseq Accession No. V28591 (Aug. 17, 1998).
Kreider et al., Geneseq Accession No. W17660 (Dec. 16, 1997).
Adams et al., Geneseq Accession No. W22670 (Mar. 19, 1998).
Godiska et al., Geneseq Accession No. W30191 (May 21, 1998).
Gish et al., Geneseq Accession No. W44398 (Jun. 11, 1998).
Garcia-Zepeda et al., Geneseq Accession No. W56087 (Aug. 17, 1998).
Bergsma et al., Geneseq Accession No. W56690 (Jul. 23, 1998).
Imai et al., Geneseq Accession No. W57475 (Sep. 7, 1998).
Hromas, Geneseq Accession No. W61279 (Sep. 24, 1998).
Adema et al., “A dendritic-cell-derived C—C chemokine that preferentially attracts naive T cells,” Nature 387:713-717 (Jun. 1997).
Berger, M.S., “Isolation of Monocyte Chemotactic Protein-4,” Clinical Res. 42(2):305A (1994).
Bischoff et al., “Monocyte Chemotactic Protein 1 Is a Potent Activator of Human Basophils,” J. Exp. Med. 175:1271-1275 (May 1992).
Blum et al., “Three Human Homologs of a Murine Gene Encoding an Inhibitor of Stem Cell Proliferation,” DNA and Cell Biol. 9(8)589-602 (1990).
Brown et al., “A Family of Small Inducible Proteins Secreted by Leukocytes are Members of a New Superfamily that Includes Leukocyte and Fibroblast-Derived Inflammatory Agents, Growth Factors, and Indicators of Various Activation Processes,” J. Immunol. 142(2):679-687 (Jan. 15, 1989).
Clements et al., “Biological and Structural Properties of MIP-1a Expressed in Yeast,” Cytokine 4(1):76-82 (Jan. 1992).
Craddock et al., “Antibodies to VLA4 integrin mobilize long-term repopulating cells and augment cytokine-induced mobilization in primates and mice,” Blood 90(12):4779-4788 (Dec. 15, 1997).
Derynck et al., “Recombinant Expression, Biochemical Characterization, and Biological Activities of the Human MGSA/gro Protein,” Biochem. 29(44):10225-10233 (1990).
Furuta et al., “Production and Characterization of Recombinant Human Neutrophil Chemotactic Factor,” J. Biochem. 106:436-441 (1989).
Garcia-Zepeda et al., “Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophila, and basophilis induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3,” J. Immunol. 157(12):5613-5626 (Dec. 15, 1996).
George et al., “Current Methods in Sequence Comparison and Analysis, Macromolecular Sequencing & Synthesis,” Alan R. Liss, Inc. Ch. 12:127-149 (1988).
Glover, David M., “Gene Cloning: The Mechanics of DNA Manipulation,” Chapman and Hall Ch. 1-8:1-218 (1984).
Graham et al., “SCI/MIP-1a: A Potent Stem Cell Inhibitor with Potential Roles in Development,” Develop. Biol. 151:377-381 (1992).
Hieshima et al., “A Novel Human CC Chemokine PARC That Is Most Homologous to Macrophage-Inflammatory Protein-1a/LD78a and Chemotactic for T Lymphocytes, but Not for Monocytes,” J. Immunol. 159:1140-1149.
Hieshima et al., “Molecular Cloning of a Novel Human CC Chemokine Liver and Activation-regulated Chemokine (LARC) Expressed in Liver,” J. Biol. Chem. 272(9):5846-5853 (Feb. 28, 1997).
Hromas et al., “Cloning and Characterization of Exodus, a Novel β-Chemokine,” Bloo
Adams Mark D.
Alderson Ralph
Appelbaum Edward R.
Gentz Solange H.
Li Haodong
Human Genome Sciences Inc.
Mertz Prema
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