Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-07
1998-10-06
Hutzell, Paula K.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C07K 1644
Patent
active
058177698
ABSTRACT:
Mammalian adipogenic factors, including purified proteins or glycoproteins, capable of inducing the adipose differentiation of adipogenic cells are disclosed, as are antibodies to such proteins, DNA encoding the proteins and host cells expressing the proteins. A method for determining the susceptibility of a subject to obesity by measuring the levels of one or more adipogenic factors in a biological fluid or tissue extract is also disclosed, as is a method for evaluating an anti-obesity drug which comprises contacting the drug with cells capable of producing one or more adipogenic factors and measuring the amount of the factors produced.
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Gaillard et al., "Fetuin modulates growth and differentiation of Ob 17 preadipose cells in serum-free hormone-supplementted medium", Biochim. Biophys. Acta 846, 185-191, 1985.
Hauner et al., "Adipogenic Factors in Human Serum Promote the Adipose Conversion of 3T3-L1 Fibroblasts", Int'l J. Obesity 10, 323-330, 1986.
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Gaillard et al., Biochim. Biophys. Acta., vol. 846, pp. 185--191, 1985.
C. Milstein et al., "Continuous cultures of fused cells secreting antibody of predefined specificity," Nature, vol. 26, Aug. 7, 1975.
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Hutzell Paula K.
W. Alton Jones Cell Science Center
Wortman Donna C.
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