Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-07
1998-12-22
Nutzell, Paula K.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
53038822, 53038885, 5303891, 5303911, 5303913, 435332, C07K 1628, C12N 512
Patent
active
058521747
ABSTRACT:
The present invention relates to receptors for advanced glycosylation endproducts derived from rat liver membranes, and that specifically comprise proteins determined to possess molecular masses of about 90 kD and 60 kD, respectively, as assessed by migration during SDS-PAGE. Partial N-terminal sequences have been determined and diagnostic and therapeutic agents, compositions and methods are proposed. Antibodies to the 90 kD and 60 kD receptor proteins are disclosed.
REFERENCES:
Yang, Z., et al. J. Exp. Med. 174: p. 515 published on Aug. 23, 1991.
Vlassara, H. et al. Proc. Natl. Acad. Sci. U.S.A. 82:5588 (1985).
Vlassara, H. et al. J. Exp. Med. 160:197 (1984).
Radoff, S. Diabetes 39:1510 (1910).
Radoff, S., et al. Arch Biochem. Biophys. 263:418 (1988).
Esposito, C. et al. J. Exp. Med. 170:1387 (1989).
Skolnik, E. et al. Diabetes J. Exp. Med. 931:939 (1991).
Cerami Anthony
Vlassara Helen
Yang Zhi
Johnson Nancy A.
Nutzell Paula K.
The Rockefeller University
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