Antibodies to ligand analogues and their utility in ligand-recep

Details Antibodies to ligand analogues and their utility in ligand-recep Antibodies to ligand analogues and their utility in ligand-recep

1990-09-14

1992-09-01

Saunders, David

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

435 6, 435 792, 435 793, 435970, 436512, 436514, 436518, 436538, 436540, 436547, 436548, 436807, 436822, 436824, 530413, G01N 33543, G01N 33558, G01N 33563, G01N 33577

Patent

active

051438526

ABSTRACT:
Means for the detection of free ligand analogue conjugate in fluids from competitive ligand-receptor assay processes. Ligand analogue antibodies that bind the ligand analogue conjugate with substantially greater affinity than their affinity for target ligand are selected and used in competitive ligand-receptor assay processes to bind the free fraction of the ligand analogue conjugate. This means permits the detection of the free fraction of ligand analogue conjugate even in the presence of substantially higher concentrations of free target ligand. For the purposes of the present invention, ligand analogue antibodies are antibodies that exhibit at least 100.times.greater affinity for the ligand analogue conjugate compared to their affinity for the target ligand.

REFERENCES:
patent: 3654090 (1972-04-01), Schuurs et al.
patent: 3817837 (1974-06-01), Rubenstein et al.
patent: 3878187 (1975-04-01), Schneider et al.
patent: 3884898 (1975-05-01), Schneider
patent: 4048298 (1977-09-01), Niswender
patent: 4108972 (1978-08-01), Dreyer
patent: 4200690 (1980-04-01), Root et al.
patent: 4203802 (1980-05-01), Rubenstein et al.
patent: 4233402 (1980-11-01), Maggio et al.
patent: 4246339 (1981-01-01), Cole et al.
patent: 4281065 (1981-07-01), Lin et al.
patent: 4298685 (1981-11-01), Parikh et al.
patent: 4366241 (1982-12-01), Tom et al.
patent: 4391904 (1983-07-01), Litman et al.
patent: 4425438 (1984-01-01), Bauman et al.
patent: 4446232 (1984-05-01), Liotta
patent: 4506009 (1985-03-01), Lenhoff et al.
patent: 4552839 (1985-11-01), Gould
patent: 4632901 (1986-12-01), Valkirs et al.
patent: 4670381 (1987-06-01), Frickey
patent: 4703017 (1987-10-01), Campbell
patent: 4727019 (1988-02-01), Valkirs et al.
patent: 4740468 (1988-04-01), Weng et al.
patent: 4745075 (1988-05-01), Hadfield
patent: 4775636 (1988-10-01), Moeremans
patent: 4806311 (1989-02-01), Greenquist
patent: 4959307 (1990-09-01), Olson
patent: 4963468 (1990-10-01), Olson
patent: 5037764 (1991-08-01), Wilk et al.
Rogers, et al. Clin. Chem. 24:95-100 (1976).

Affiliated with

Also associated with

Rating

Antibodies to ligand analogues and their utility in ligand-recep does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibodies to ligand analogues and their utility in ligand-recep, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies to ligand analogues and their utility in ligand-recep will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-767435