Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1992-02-19
1994-03-29
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530324, 530327, 53038824, 5303892, 5303911, 530808, 530845, 424 858, C07K 1506, C07K 1528, A61K 39395
Patent
active
052986055
ABSTRACT:
This invention is directed to antibodies which react with human islet amyloid polypeptide and which do not significantly react with insulin or calcitonin gene-related peptides. Preparations of antibodies are provided which bind to islet amyloid polypeptide (IAPP) which is substantially free of islet amyloid, and when isolated from humans, has the following amino acid sequence in positions 1-37:
REFERENCES:
patent: 4530838 (1985-07-01), Evans et al.
patent: 5112945 (1992-05-01), Westermark et al.
patent: 5116948 (1992-05-01), Westermark et al.
patent: 5124314 (1992-06-01), Cooper
patent: 5175146 (1992-12-01), Basava et al.
P. Westermark, et al. Diabetologia 24:342-6 (1983). "Islet amyloid in type 2 (non-insulin-dependent) . . . ".
Kohler, et al. Nature 256:495-7 (1975) "Continuous cultures of fused cells secreting . . . ".
R. Scopes, Protein Purification (1982), pp. 101-111. Springer.varies.Verlag.
Antibodies: A Laboratory Manual, Harlow and Lane, editors, Cold Spring Harbor, publisher, Index pages (1988).
Mosselman et al., "The Complete Islet Amyloid Polypeptide Precursor is Encoded by Two Exons", FEBS Letters, 247:154-158 (1989).
Sigma Catalog, p. 1086 (1992).
Amara et al., "Alternative RNA Processing in Calcitonin Gene Expression Generates mRNAs Encoding Different Polypeptide Products", Nature, 298:240 (1982).
Steenbergh et al., "A Second Human Calcitonin/CGRP Gene", FEBS Letters, 183:403 (1985).
T.-Y. Fang et al., Pancreas, 1, 293 (1986).
C. Betscholtz et al., Exper. Cell. Res., 183, 484 (1989).
Per Westermark et al., Diabetologia, 24, 342 (1983).
T. D. O'Brien, Am. J. Pathol., 119, 430 (1985).
K. H. Johnson et al., Vet. Pathol., 22, 463 (1985).
K. Higuchi et al., Lab. Invest., 48, 231 (1983).
C. Betsholtz et al., Diabetes, 39, 118 (1990).
P. Westermark, PNAS USA, 84, 3881 (Jun. 1987).
A. Clark, The Lancet, 231 (Aug. 1, 1987).
Johnson Kenneth H.
Westermark Per
Cunningham T.
Nucker Christine M.
Regents of the University of Minnesota
LandOfFree
Antibodies to islet amyloid polypeptide (IAPP) and subunits ther does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies to islet amyloid polypeptide (IAPP) and subunits ther, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies to islet amyloid polypeptide (IAPP) and subunits ther will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-792963