Antibodies to interleukin-20 and method for inhibiting...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C530S387200

Reexamination Certificate

active

07435800

ABSTRACT:
Antibody to human IL-20 protein, a method for generation thereof and cells producing this antibody are disclosed. The antibody of the present invention has specificity to neutralizing hIL-20W-induced CPAE proliferation activity, and is useful for treating IL-20-induced inflammation, such as artheriosclerosis and rheumatoid arthritis.

REFERENCES:
Hunt et al., “Ultraviolet B Light Stimulates Interleukin-20 Expression by Human Epithelial Keratinocytes,”Photochemistry and Photobiology, Sep./Oct. 2006, vol. 82, pp. 1292-1300.
Hsieh et al., “Interleukin-20 promotes angiogenesis in a direct and indirect manner,”Genes and Immunology, 2006, vol. 7, pp. 234-242.
International Search Report and Written Opinion for International Application No. PCT/US2006/46802, dated Dec. 19, 2007, 8 pages.

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