Antibodies to intereleukin-1 antagonists

Details Antibodies to intereleukin-1 antagonists Antibodies to intereleukin-1 antagonists

1997-08-13

1999-11-09

Mertz, Prema

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303871, 5303881, 53038823, 5303891, 5303892, C07K 1618

Patent

active

059817135

ABSTRACT:
A novel interleukin-1 antagonist active against both IL-1.alpha. and IL-1.beta. and DNA encoding same/re described. Antibodies specific for the novel IL-1 antagonist and prophylatic, therapeutic and diagnostic uses of the IL-1 antagonist in pathologies associated with IL-1 production are also described.

REFERENCES:
patent: 5075222 (1991-12-01), Hannum et al.
McColl et al. J. Exp. Med -vol. 176, pp. 593-598, Aug. 1992.
Hannum, Charles H. et al., "Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor." Nature, vol. 343, pp. 336-340 (Jan. 25, 1990).
Eisenberg, Stephen P. et al., "Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist." Nature, vol. 343, pp. 341-346 (Jan. 25, 1990).
Carter, D.B. et al., "Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein." Nature, vol. 344, pp. 633-638 (Apr. 12, 1990).
Bienkowski, Michael J. et al., "Purification and characterization of interleukin-1 receptor level antagonist proteins from THP-1 cells." Journal of Biological Chemistry, vol. 265, No. 24, pp. 14505-14511(1990).
Stockman et al. Secondary Strucutre and Topology of Interleukin-1 Receptor Antagonist Protein Determined by Heteronuclear Three-Dimensional NMR Spectroscopy, American Chemical Society vol. 31, No. 23, pp. 5237-5244, Jun. 19, 1992.
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Haskill et al, cDNA Cloning of an Intracelluar Form of the Human Interleukin 1 Receptor Antagonist Associated with Epithelium, Proc. Natl. Acad. Sci., vol. 88 pp. 3681-3685, May 1991.
C. Butcher et al. "Comparison of two promoters controlling expression of secreted or intracellular IL-1 receptor antagonist", Journal of Immunology, vol. 153, Jul. 1994, pp. 701-711.
C. A. Dinarello et al. "Blocking IL-1: Interleukin 1 receptor antagonist in vivo and in vitro", Immunology Today, vol. 12, No. 11, 1991, Cambridge GB, pp. 404-410.
N.F. Zander et al. "cDNA cloning and complete primary structure of skeletal muscle phosphorylase kinase (alpha subunit)", Proceedings of the National Academy of Sciences USA, vol. 85, May 1988, Washington US, pp. 2929-2933.
Abstract, EMBL database entry SKADECYC Accession No. X56042 (version 1); Nov. 19, 1990; Young et al.
M. Muzio et al. "Cloning and charcterization of a new isoform of the interleukin 1 receptor antagonist", Journal of Experimental Medicine, vol. 182, No. 2, Aug. 1, 1995, pp. 623-628.

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