Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-06-20
2000-05-16
Saunders, David
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303871, 5303881, 5303882, 53038822, 5303887, 53038873, 53038875, 5303891, 5303896, 435 71, 435 72, 435 721, 435 724, C07K 1618, C07K 1628, G01N 3353
Patent
active
060639067
ABSTRACT:
The present invention relates to antibodies that bind to a highly charged region of the integrin .alpha..sup.E subunit and its functional equivalents. The antibodies are useful in screening assays to identify agents which mimic the ligand-binding site on the integrin .alpha..sup.E.
REFERENCES:
patent: 3652761 (1972-03-01), Weetal
patent: 4478946 (1984-10-01), Van der Merwe et al.
patent: 4554088 (1985-11-01), Whitehead et al.
patent: 5002873 (1991-03-01), St. John et al.
patent: 5120830 (1992-06-01), Santoro
patent: 5188959 (1993-02-01), Haberman
patent: 5206345 (1993-04-01), Masinovksy et al.
patent: 5211657 (1993-05-01), Yamada et al.
patent: 5432018 (1995-07-01), Dower et al.
patent: 5594120 (1997-01-01), Brenner et al.
patent: 5610281 (1997-03-01), Brenner et al.
T. Ferguson et al., Two integrin-binding peptides abrogate T cell-mediated immune response in vivo, Proc. Natl. Acad. Sci. USA, vol. 88: 8072-8076, Sep. 1991.
D. Taylor et al., A Peptide Corresponding to GPIIb.alpha. 300-312, a Presumptive Fibrinogen .lambda.-Chain Binding on the Platelet Integrin GPIIb/IIIa, Inhibits the Adhesion of Platelets to at Least Four Adhesive Ligands, J. Bio Chem.; Jun. 15, 1992: 267, 11729-11733.
N. Vedder et al., Inhibition of leukocyte adherence by anti-CD 18 monoclonal antibody attenuates reperfusion injury in the rabbit ear, Proc. Natl. Acad. Sci. USA, vol. 87: 2643-2646, Apr. 1990.
T. Yednock et al., Prevention of experimental autoimmune encephalomyelitis by antibodies against .alpha.4.beta.1 integrin, Nature, 356, Mar. 5, 1992:63-66.
Cepek, K.L. et al., Integrin .alpha..sub.E .beta..sub.7 Mediates Adhesion of T Lymphocytes to Epithelial Cells, J. Immunol., 150: 3459-3470 (1993).
Parker, C.M. et al., A family of .beta..sub.7 integrins on human mucosal lymphocytes, Proc. Natl. Acad. Sci. USA 89: 1924-1928 (1992).
Hochstenbach, F. et al., Characterization of a Third Form of the Human T Cell Receptor, J. Exp. Med. 168:761-776 (1988).
Moller, P. et al., Rapid Communication-Monoclonal Antibody HML-1, a marker for Intraepithelial T Cells and Lymphomas Derived Thereof, Also Recognizes Hairy Cell Leukemia and Some B-cell Lymphomas, Amer. J. Path. 136: 509-512 (1990).
Visser, L. et al., Monoclonal Antibodies Reactive with Hairy Cell Leukemia, Blood 74: 320-325 (1989).
Cerf-Bensussan, N. et al., A monoclonal antibody (HML-1) defining a novel membrane molecule present on human intestinal lymphocytes, Eur. J. Immunol. 17: 1279-1285 (1987).
Kruschwitz, M. et al., Ber-ACT8: New monoclonal antibody to the mucosa lymphocyte antigen, J. Clin. Path 44, 636-645 (1991).
Pallesen, G. et al., Specificity of monoclonal antibody HML-1, Lancet 335: 537 (1990).
Visser, L. et al., Induction of B-cell chronic lymphocytic leukaemia and hairy cell leukaemia like phenotypes by phorbol ester treatment of normal peripheral blood B-cells, Brit. J. Haematol. 75: 359-365 (1990).
T. Springer, Adhesion receptors of the immune system, Nature, 346: 425-434 (1990).
S. Albelda, Biology of Disease--Role of Integrins and Other Cell Adhesion Molecules in Tumor Progression and Metastasis, Laboratory Investigation, 68: 4-17 (1993).
Cerf-Bensussan, N. et al., The human intraepithelial lymphocyte marker HML-1 is an integrin consisting of a .beta.7 subunit associated with a distinctive .alpha. chain, Eur. J. Immunol., 22,:273-277 (1992).
Krissansen, G.W. et al., Immunologic and structural relatedness of the integrin .beta..sub.7 complex and the human intraepithelial lymphocyte antigen HML-1, FEBS Letts. 296: 25-28 (1992).
A. Leff et al., Inflammation and cell-cell interactions in airway hyperresponsiveness, Am. Physiological Soc., 189-206 (1991).
R. Seth et al., ICAM-2 peptides mediate lymphocyte adhesion by binding to CDIIa/CD18 and CD49d/CD29 integrins, FEBS Letters 282: 193-196 (1991).
M. Conrad et al., A concise Review: Iron Absorption--The Mucin-Mobilferrin-Integrin Pathway, A Competitive Pathway for Metal Absorption, Am. J. Hematology, 42: 42-67 (1993).
S. Mette et al., Distribution of Integrin Cell Adhesion Receptors on Normal Bronchial Epithelial Cells and Lung Cancer Cells In Vitro and In Vivo, Am. J. Respir. Cell Mol. Biol., 8: 562-572 (1993).
E. Uhlmann et al.,Antisense Oligonucleotides: A New Therapeutic Principle Chemical Reviews, vol. 90(4): 543-584 (1990).
J. Holt et al., An Oligomer Complementary to c-myc MRNA Inhibits Proliferation of HL-60 Promyelocytic Cells and Induces Differentiation, Mol. Cell Biol., 8(2): 963-973 (1988).
M. Cooney et al., Site-Specific Oligonucleotide Binding Represses Transcription of the Human c-myc Gene In Vitro, Science, vol. 241: 456-459 (1988).
C. Helene et al., Oligodeoxynucleotides covalently linked to intercalating agents: a new class of gene regulatory substances, Biochimie, 67: 777-783 (1985).
W. James, Towards gene-inhibition therapy: a review of progress and prospects in the field of antiviral antisense nucleic acids and ribozymes, Antiviral Chem. & Chemo. 2(4): 191-214 (1991).
R. Weiss, Upping the Antisense Ante-Scientists bet on profits from reverse genetics, Science News, 139: 108-109 (1991).
M. Arnaout et al., Molecular cloning of the .alpha. subunit of human and guinea pig leukocyte adhesion Mol: Chromosomal localization and homology to the .alpha. subunits of integrins, Proc. Natl. Acad. Sci. USA, 85: 2776-2780 (1988).
T. Lallier et al., Inhibition of Neural Crest Cell Attachment by Integrin Antisense Oligonucleotides, Science, 259: 692-695 (1993).
A. Shatzman et al., Expression, Indentification, and Characterization of Recombinant Gene Products in Escherichia coli, Methods in Enzymology, 152: 661-673 (1986).
Roberts, K. et al., The Mucosal T Cell Integrin Alpha -M-290-Beta-7 Recognizes a Ligand on Mucosal Epithelial Cell Lines, Eur. J. Immunol. 23 (7): 1630-1635 (1993).
Shaw, S. et al., Molecular Cloning of the Human Mucosal Lymphocyte Intergrin Alpha-E Subunit: Unusual Structure and Restricted RNA Distribution, Journal of Biological Chemistry, 269(8): 6016-6025 (1994).
Tidd, D., A Potential Role for Antisense Oligonucleotide Analogues in the Development of Oncogene Targeted Cancer Chemotherapy, Anticancer Research 10: 1169-1182 (1990).
Wu-Pong, S., Oligonucleotides: Opportunities for Drug Therapy and Research, Pharm. Tech.:102-114 (1994).
Westermann, P., et al., Inhibition of expression of SV40 virus large T-antigen by antisense oligodeoxyribonucleotides, Biomed. Biochim. Acta 48(1): 85-93 (1989).
Herrenknecht et al., Characterization of Recombinant E-Cadherin (Uvomorulin) Expressed in Insect Cells, Journal of Cell Science, vol. Supp. 17, 1993, pp. 147-154.
M. Wheelock et all, Soluble 80-id Fragment of Cell-CAM 120/80 Disrupts Cell-Cell Adhesion, Journal of Cellular Biochemistry, vol. 34, No. 3, Jul. 1987.
M. Takeichi et al., Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator, Science, vol. 251, No. 5000, Mar. 22, 1991, pp. 1451-1455.
M. Katayama et al., Soluble E-Cadherin Fragments Increased in Circulation of Cancer Patients, British Journal of Cancer, vol. 69, No. 3, Mar. 1994.
P. Karecla et al., Recognition of E-Cadherin on Epithelial Cells by the Mucosal T Cell Integrin AlphaM290beta7 (AlphaEbeta7), European J. Of Immunology, vol. 25, No. 3, Mar. 1995.
Roberts and O'Connell, "Binding of Intreapithelial Lymphocytes to Colon Cancer Cells is Mediated by HMLI and LFA1," A685, K.C. Ebert., Depts. Of Medicine and Surgery, UMDMJ-Robert Wood Johnson Medical School, New Brusnwick, NH (Apr. 1992).
Visser, Dabbagh, and Poppema, "Reactivity of Monoclonal Antibody B-ly7 with a Subset of Activated T Cells and T-Cell Lymphomas," Hematol Pathol 6(1):37-42 (1992).
Harris, W.J., et al., "Therapeutic Antibodies--the Comingof Age,"TIBTECH, 11:42-44, Feb. 1993.
Osband, M.E., et al., "Problems in the Investigational Study and Clinical Use of Cancer Immunotherapy," Immunology Today, 11(6):193-195, 1990.
Waldmann, T.A., "Monoclonal Antibodies in Diagnosis and Therapy," Science, 252:1657-1662, Jun. 1991.
Shirayoshi, Y. et al., "N-Linked Oligosaccharides Are Not Involved in the Function of a Cell-Cell Binding Glycoprotein E-Cadherin," Cell Structure and Function, 11:245-252, 1986.
Brenner Michael B.
Parker Christina M.
Brigham and Women's Hospital, Inc.
Gambel Phillip
Saunders David
LandOfFree
Antibodies to integrin alpha subunit does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies to integrin alpha subunit, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies to integrin alpha subunit will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-259886