Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1998-09-28
2000-12-26
Mertz, Prema
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303871, 5303881, 53038823, 53038824, 5303891, 5303892, C07K 1618, C07K 1622, C07K 1624
Patent
active
061661856
ABSTRACT:
The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.
REFERENCES:
Harlow et al. (1988) Antibodies `A Laboratory Manual`. Cold Spring Harbor Laboratory p. 76, Chapter 5.
Lerner (1982) Native vol. 299 pp. 592-596.
Nomura et al. (1994) DNA Research vol. 1, Supplement, pp. 47-56.
Aldrich Thomas H.
Bruno JoAnne
Davis Samuel
Goldfarb Mitchell
Jones Pamela F.
Cobert Robert J.
Mertz Prema
Palladino Linda O.
Regeneron Pharmaceuticals Inc.
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