Antibodies to human PF4A receptor and compositions thereof

Details Antibodies to human PF4A receptor and compositions thereof Antibodies to human PF4A receptor and compositions thereof

1996-08-22

1998-07-07

Eisenschenk, Frank C.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Binds antigen or epitope whose amino acid sequence is...

4241431, 5303879, 5303876, 53038822, 435 724, C07K 1600, C12P 2108, A61K 39395

Patent

active

057764573

ABSTRACT:
cDNAs encoding a class of receptors, including the IL-8 receptors, have been identified in human tissue. Recombinantly produced PF4ARs are used in the preparation and purification of antibodies capable of binding to the receptors, and in diagnostic assays. The antibodies are advantageously used in the prevention and treatment of inflammatory conditions.

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Jazin et al., "A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells" Regulatory Peptides 47:247-258 (1993).
Loetscher et al., "Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes" Journal of Biological Chemistry 269(1):232-237 (1994).
Nomura, H. et al., "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors" International Immunology 5(10):1239-1249 (1993).
Herzog et al., "Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: lack of NPY binding and activation" DNA and Cell Biology 12(6): 465-471 (1993).

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