Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1993-06-11
1996-08-06
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530351, 5303892, 424 852, A61K 3514, A61K 39395, C07K 1454
Patent
active
055435033
ABSTRACT:
cDNAs encoding a class of receptors, including the IL-8 receptors, have been identified in human tissue. Recombinantly produced PF4ARs are used in the preparation and purification of antibodies capable of binding to the receptors, and in diagnostic assays. The antibodies are advantageously used in the prevention and treatment of inflammatory conditions.
REFERENCES:
Thomas et al. 1991 J. Biol. Chem 266(23):14839.
Chuntharapai et al 1993 J. Immunol. 150 (8pt2):126A.
Holmes et al. 1991 Science 253:1278.
Murphy et al. 1991 Science 253:1280.
Lee et al 1992 J Biol Chem 267(23):16283.
Beckmann, et al., "Molecular Characterization of Interleukin-8 Receptor" Biochem. Biophys. Res. Comm. 179(2):784-489 (Sep. 1991).
Besemer, et al., "Specific Binding, Internalization, and Degradation of Human Neutrophil Activating Factor by Human Polymorphonuclear Leukocytes" J. Biol. Chem. 264(29):17409-17415 (Oct. 1989).
Boulay, et al., "Synthesis and Use of a Novel N-Formyl Peptide Derivative to Isolate a Human N-Formyl Peptide Receptor cDNA" Biochem. Biophys. Res. Comm. 168(3):1103-1109 (May 1990).
D'Andrea et al., "Expression Cloning of the Murine Erythropoietin Receptor" Cell 57:277-285 (Apr. 1989).
Dixon, et al., "Structure-Function Analysis of the Beta-Adrenergic Receptor" Cold Spring Har. Sym. Quant. Biol. 53:487-497 (1988).
Gerard et al., "The chemotactic receptor for human C5a anaphylatoxin" Nature 349:614-617 (Feb. 1991).
Grob et al., "Characterization of a Receptor for Human Monocyte-derived Neutrophil Chemotactic Factor/Interleukin-8" J. Biol. Chem. 265(14):8311-8316 (May 1990).
Lee, et al., "Characterization of Two High Affinity Human Interleukin-8 Receptors" J. Biol. Chem. 267(23):16283-16287 (Aug. 1992).
Ramachandran, et al., "The Structural and Functional Interrelationships of Muscarinic Acetylcholine Receptor Subtypes" BioEssays 10(2 &3):54-57 (Feb., Mar. 1989).
Saragovi, et al., "The Murine Interleukin 2 Receptor . . . " J. of Immunology 139 (6):1916-1926 (Sep. 1987).
Sims, et al., "cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily" Science 241:585-589 (Jul. 1988).
Chuntharapai et al., "Neutralizing monoclonal antibodies to human IL-8 receptor A map to the NH2-terminal region of the receptor" J. Immunol. 152(4):1783-1789 (1994).
Ye et al., "Inhibition of IL-8 binding to the type B IL-8 receptor by an anti-IL-8 receptor antibody" FASEB J. (Abstract #786) 8(4-5):A136 (1994).
Chuntharapai Anan
Hebert Caroline
Kim K. Jin
Lee James
Carlson K. Cochrane
Genentech Inc.
Love Richard B.
Wax Robert A.
LandOfFree
Antibodies to human IL-8 type A receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies to human IL-8 type A receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies to human IL-8 type A receptor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2191912