Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds antigen or epitope whose amino acid sequence is...
Reexamination Certificate
2006-07-11
2009-02-17
Belyavskyi, Michail A (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds antigen or epitope whose amino acid sequence is...
C530S387100, C530S387900
Reexamination Certificate
active
07491392
ABSTRACT:
An IL-1β binding molecule, in particular an antibody to human IL-1β, especially a human antibody to human IL-1β is provided, wherein the CDRs of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease or disorder, e.g. osteoarthritis, osteroporosis and other inflammatory arthritides.
REFERENCES:
patent: 4935343 (1990-06-01), Allison et al.
patent: 6632927 (2003-10-01), Adair et al.
patent: 0 218 531 (1986-10-01), None
patent: 0 491 031 (1991-07-01), None
patent: 90/06371 (1989-12-01), None
patent: 91/09967 (1990-12-01), None
patent: 95/01197 (1994-07-01), None
patent: 95 01997 (1995-01-01), None
patent: 99/42075 (1999-02-01), None
Knappik et al ., Journal of Molecular Biology, 2000, V.1 p. 57-86.
Pascalis et al. The Journal of Immunology (2002) 169, 3076-3084.
Matsuda et al., “The Complete Nucleotide Sequence of the Human Immunoglobulin Heavy Chain Variable Region Locus”, J. Exp. Med., vol. 188, No. 11, pp. 2151-2162, (Dec. 7, 1998).
Le Xiaozhong, “Current Protocols of Biotechnology”, Beijing Normal University Press, line 15 p. 256, line 10 p. 257, (1999).
Massone et al, “Mapping of Biologically Relevant Sites on Human II-1Beta Using Monoclonal Antibodies”, The Journal of Immunology, vol. 140, No. 11, pp. 3812-3816 (1988).
Simon et al, “Mapping of Neutralizing Epitopes and the Receptor Binding Site of Human Interleukin 1Beta*” The Journal of Biological Chemistry, vol. 268, No. 13, pp. 9771-9779 (1993).
Herzbeck et al., “Functional and Molecular Characterization of a Monoclonal Antibody Against the 165-186 Peptide of Human IL-1Beta”, Scand. J. Immunol., vol. 30, pp. 549-562, (1989).
Paul, Fundamental Immunology, 1999, oo.37, 43, 58, 59.
Rudikoff et al., Proc Natl Acad Sci USA, 1982, vol. 79, p. 1979.
Panka et al., Proc Natl Acad Sci USA, vol. 85, 3080-3084, May, 1988.
Colman et al., Research in Immunology, (145(1):33-36, 1994.
Di Padova Franco E
Gram Hermann
Belyavskyi Michail A
Fischer Leslie
McAvoy Cozette M.
Novartis AG
Waibel Peter J.
LandOfFree
Antibodies to human IL-1β does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies to human IL-1β, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies to human IL-1β will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4092903