Antibodies to human gastrin-releasing peptide precursor and use

Details Antibodies to human gastrin-releasing peptide precursor and use Antibodies to human gastrin-releasing peptide precursor and use

1996-05-17

1998-06-23

Huff, Sheela

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435 791, 435 792, 435 793, 435 794, 435 795, 435325, 435326, 435330, 435331, 435344, 5303877, 5303882, 5303879, 53038824, 5303888, 436523, 436524, 436575, 436526, 436527, 436528, 436529, 436530, G01N 3353, G01N 33542, G01N 33537, G01N 33543

Patent

active

057703850

ABSTRACT:
Antibodies made to a flanking region GPR(31-98) in human gastrin-releasing peptide (GRP) precursor. Since the antibodies have high affinity to GRP precursor, and the GPR precursor is highly stable in the blood, then lung cancer, especially small cell lung cancer can be diagnosed with high reliability by detecting or measuring GRP precursor in the blood of a patient using the present antibodies.

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Goodman Basic Clinical Immunology, Fudenberg et al., (Ed.), Lang Medical Publications, pp. 32-40, (1976).
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Cuttitta et al. Journal of Clinical Endocrinology and Metabolism, vol. 67, No. 3, pp. 576-583, (1988).
Bork et al. Biosis Abstract No. 88:377073, Eur. J. Cancer Clin. Oncol. 24(6), pp. 1033-1038, (1988).
Maruno et al. Biosis Abstract No. 89:138029, Cancer Res. 49(3), pp. 629-632, (1989).

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