Antibodies to human gastrin-releasing peptide precursor and use

Details Antibodies to human gastrin-releasing peptide precursor and use Antibodies to human gastrin-releasing peptide precursor and use

1993-02-11

1996-08-27

Chan, Christina Y.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 792, 43524027, 5303877, 5303879, 53038824, 5303888, 53038885, 5303892, 5303897, G01N 3353, C12N 512, C07K 1626

Patent

active

055500269

ABSTRACT:
Antibodies made to a flanking region GPR(31-8) in human gastrin-releasing peptide (GRP) precursor. Since the antibodies have high affinity to GRP precursor, and the GPR precursor is highly stable in the blood, then lung cancer, especially small cell lung cancer can be diagnosed with high reliability by detecting or measuring GRP precursor in the blood of a patient using the present antibodies.

REFERENCES:
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Sunday et al., Human Pathology, vol. 22, No. 10, pp. 1030-1039 (1991).
Sunday et al., 45th Annual National Meeting of the American Federation for Clinical Research, Washington D.C., Apr. 29-May 2, 1988, Clinical Research, vol. 36(3) p. 500A 1988.
T. Goodman, Basic & Clinical Immunology, Fudenberg et al. (ed.), Lange Medical Publications, Los Altos, pp. 32-40, 1976.
Kohler et al., Nature, vol. 256, pp. 495-497 (1975).
Holst et al., Journal of Clinical Oncology, vol. 7, No. 12, pp. 1831-1838, (1989).
W. Cuttitta et al., Journal of Clinical Endocrinology and Metabolism, vol. 67, No. 3, pp. 576-583 (1988).
US News & World Report, p. 61, Aug. 15, 1994.

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