Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-09-13
2008-09-09
Mertz, Prema (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387300, C435S326000, C424S001490
Reexamination Certificate
active
07423129
ABSTRACT:
The invention relates to isolated and/or recombinant nucleic acids which encode a human chemotactic cytokine designated human eotaxin, and to isolated and/or recombinant human eotaxin proteins or polypeptides, including synthetic polypeptides. The invention further relates to recombinant nucleic acid constructs, comprising a nucleic acid which encodes a human eotaxin, a portion thereof, or a variant; to host cells comprising such constructs, useful for the production of recombinant human eotaxin; and to antibodies reactive with human eotaxin, useful in in vitro methods, diagnosis and/or therapy. Also provided are methods of use of the eotaxin proteins, e.g., in the recruitment of eosinophils to a particular site or in the treatment of allergic conditions. Human eotaxins can be used to identify inhibitors (e.g., antagonists) or promoters (agonists) of human eotaxin, which can be used to selectively modulate leukocyte function, in inflammatory and autoimmune diseases, or in infections.
REFERENCES:
patent: 5993814 (1999-11-01), Williams et al.
patent: 6001649 (1999-12-01), Caput et al.
patent: 6031080 (2000-02-01), Williams et al.
patent: 6403782 (2002-06-01), Luster et al.
patent: 6780973 (2004-08-01), Luster et al.
patent: WO 90/07863 (1990-07-01), None
patent: WO 95/07985 (1995-03-01), None
patent: WO 96/25497 (1996-08-01), None
patent: WO 97/12914 (1997-04-01), None
patent: WO 97/46683 (1997-12-01), None
Baggiolini, M. and C.A. Dahinden, “CC Chemokines in Allergic Inflammation,”Immunol. Today, 15(3):127-133 (1994).
Cunningham, B.C. and J.A. Wells, “High-Resolution Epitope Mapping of hGH-Receptor Interactions by Alanine-Scanning Mutagenesis,”Science, 244:1081-1085 (1989).
Garcia-Zepeda, E.A. et al., “Human Eotaxin is a Specific Chemoattractant for Eosinophil Cells and Provides a New Mechanism to Explain Tissue Eosinophilia,”Nature Medicine,2(4):449-456 (1996).
George, D.G. et al., “Current Methods in Sequencing Comparison and Analysis,” In Macromolecular Sequencing and Synthesis, D.H. Schlesinger, ed. (NY:Alan R. Liss, Inc.), Ch. 12, pp. 127-149 (1988).
Griffiths-Johnson, D.A. et al., “The Chemokine, Eotaxin, Activates Guinea-Pig Eosinophils in vitro and Causes Their Accumulation into the Lung in vivo,”Biochemical and Biophysical Research Communications,197(3):1167-1172 (1993).
Holst, B., et al., “Steric Hindrance Mutagenesis versus Alanine Scan in Mapping of Ligand Binding Sites in the Tachykinin NK1Receptor,”Mol. Pharmacol.,53:166-175 (1998).
Jose, P.J. et al., “Eotaxin: Cloning of an Eosinophil Chemoattractant Cytokine and Increased mRNA Expression in Allergen-Challenged Guinea-Pig Lungs,”Biochemical and Biophysical Research Communications,205(1):788-794 (1994).
Jose, P.J., et al., “Eotaxin: A Potent Eosinophil Chemoattractant Cytokine Detected in a Guinea Pig Model of Allergic Airways Inflammation,”J. Exp. Med.,179:881-887 (1994).
Kameyoshi, Y. et al., “Cytokine RANTES Released by Thrombin-stimulated Platelets Is a Potent Attractant for Human Eosinophils,”J. Exp. Med.,176:587-592 (1992).
Kitaura, M. et al., “Molecular Cloning of Human Eotaxin, an Eosinophil-selective CC Chemokine, and Identification of a Specific Eosinophil Eotaxin Receptor, CC Chemokine Receptor 3,”The Journal of Biological Chemistry,271(13):7725-7730 (1996).
Kleemann, R. et al., “Characterization of Catalytic Centre Mutants of Macrophage Migration Inhibitory Factor (MIF) and Comparison to Cys81Ser MIF,”Eur. J. Biochem.,261:753-766 (1999).
Mikayama, T., et al., “Molecular Cloning and Functional Expression of a cDNA Encoding Glycosylation-Inhibiting Factor,”Proc. Natl. Acad. Sci. USA,90:10056-10060 (1993).
Miller, M.D., et al., “Biology and Biochemistry of the Chemokines: A Family of Chemotactic and Inflammatory Cytokines,”Crit. Rev. Immunol.,12(1,2):17-46 (1992).
Ponath, P.D. et al., “Cloning of the Human Eosinophil Chemoattractant, Eotaxin Expression, Receptor Binding, and Functional Properties Suggest a Mechanism for the Selective Recruitment of Eosinophils,”J. Clin. Invest.97(3):604-612 (1996).
Rot, A., et al., “RANTES and Macrophage Inflammatory Protein 1α Induce the Migration and Activation of Normal Human Eosinophil Granulocytes,”J. Exp. Med.176(6):1489-1495 (1992).
Rothenberg, M.E. et al., “Constitutive and Allergen-induced Expression of Eotaxin mRNA in the Guinea Pig Lung,”J. Exp. Med.,181:1211-1216 (1995).
Rothenberg, M.E. et al., “Murine Eotaxin: An Eosinophil Chemoattractant Inducible in Endothelial Cells and in Interleukin 4-induced Tumor Suppression,”Proc. Natl. Acad. Sci. USA,92:8960-8964 (1995).
Schröder, J.-M. et al., “Platelets Secrete and Eosinophil-Chemotactic Cytokine Which is a Member of the C-C-Chemokine Family,”Advances in Exp. Med. and Biology351:119-128 (1993).
Tepper, R.I. et al., “Murine Interleukin-4 Displays Potent Anti-tumor Activity in Vivo,”Cell,57:503-512 (1989).
Tomura, T. et al., “Immunosuppressive Activities of Recombinant Glycosylation-Inhibiting Factor Mutants,”J. Immunol.,162:195-202 (1999).
Wardlaw, A.J. et al., “Platelet-Activating Factor, A Potent Chemotactic and Chemokinetic Factor for Human Eosinophils,”J. Clin. Invest.78:1701-1706 (1986).
Watarai, H. et al., “Posttranslational Modification of the Glycosylation Inhibiting Factor (GIF) Gene Product Generates Bioactive GIF,”Proc. Natl. Acad. Sci. U.S.A.,97(24):13251-13256 (2000).
Voet, D and Voet, J.G., Biochemistry, John Wiley & Sons, Inc. p. 126-128 and 228-234 (1990).
Mackay Charles
Newman Walter
Ponath Paul D.
Qin Shixin
Ringler Douglas J.
Hamilton Brook Smith & Reynolds P.C.
Mertz Prema
Millennium Pharmaceuticals Inc.
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