Antibodies to human cripto protein

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 723, 5303871, 5303879, 5303882, 5303888, 53038885, 5303897, 5303891, C07K 1630, G01N 3353

Patent

active

057926166

ABSTRACT:
A new human gene designated as "CRIPTO" gene has been identified and cloned. CRIPTO gene products and derivatives thereof have been obtained and various utilities of the same have been described. Polyclonal and monoclonal antibodies to the human CRIPTO protein have been described. Association of CRIPTO gene with cancers, such as colorectal cancer and breast carcinoma, has been indicated.

REFERENCES:
Ciccodicola, EMBO 8:1987-1991, 1989.
Kobrin, J. Biol Chem 261:14414-14419, 1986.
Dono, Am. J. Hum. Genet. 49:555-565, 1991.

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