Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-06
1997-12-02
Scheiner, Toni R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303871, 5303875, 5303882, 5303888, 53038885, 5303872, G01N 33574, C07K 1630, C07K 1642
Patent
active
056937636
ABSTRACT:
A glycoprotein antigen which is generally characteristic of human carcinomas, regardless of the tissue associated with the carcinoma--human carcinoma antigen (HCA)--and which is generally not present on normal human cells. Immunodeterminant-containing fragments of HCA substantially separated from elements of HCA's naturally occurring environment are also disclosed. HCA is generally characterized by: a) a molecular weight in excess of 750,000; b) carbohydrate moieties characteristic of mucin-type glycoproteins and comprising a relatively high proportion of sialic acid, galactose, and N-acetylgalactosamine residues (e.g., at least 50% of the carbohydrate residues are sialic acid, galactose, or N-acetylgalactosamine residues); c) an isoelectric point below pH 3.0; d) presence generally on human carcinoma cells; e) absence generally from non-transformed human cells; f) at least one immunodeterminant that specifically reacts with anti-murine epiglycanin antibody AE3; and g) general insolubility in aqueous fluids (e.g., a phosphoric acid or an HCl solution) below pH 2.0 Also disclosed are antibodies to HCA, immunoassays for HCA, in vivo imaging using HCA-binding antibodies and therapeutics using HCA or anti-idiotypic HCA antibodies.
REFERENCES:
patent: Re32417 (1987-05-01), Burchiel et al.
patent: 3867363 (1975-02-01), Hansen
patent: 3956258 (1976-05-01), Hansen
patent: 3967638 (1976-07-01), Tondreau
patent: 4086217 (1978-04-01), Hansen
patent: 4180499 (1979-12-01), Hansen
patent: 4628032 (1986-12-01), White et al.
patent: 4708930 (1987-11-01), Kortright et al.
patent: 4713352 (1987-12-01), Bander et al.
patent: 4732862 (1988-03-01), Bartorelli
patent: 4743543 (1988-05-01), Kortright
patent: 4837171 (1989-06-01), Codington
patent: 4888275 (1989-12-01), Holmgren et al.
patent: 4892934 (1990-01-01), Yoshida et al.
patent: 4892935 (1990-01-01), Yoshida et al.
patent: 4914021 (1990-04-01), Toth et al.
patent: 4918164 (1990-04-01), Hellstom et al.
patent: 4921789 (1990-05-01), Salem et al.
patent: 4921790 (1990-05-01), O'Brien
patent: 4939240 (1990-07-01), Chu et al.
patent: 4963484 (1990-10-01), Kufe
patent: 5019497 (1991-05-01), Olsson
patent: 5030621 (1991-07-01), Bystryn
patent: 5053489 (1991-10-01), Kufe
patent: 5110911 (1992-05-01), Samuel et al.
patent: 5118611 (1992-06-01), Smith et al.
Barak, M., et al., "CA-15.3, TPA and MCA as Markers for Breast Cancer", 1990, Eur. J. Cnacer, vol. 26, pp. 577-580.
Becker, S.N., et al., "Scanning Electron Microscopy of Alcohol-Fixed Cytopathology Speciments", 1981, Acta Cytologica, vol. 25, pp. 578-584.
Bhavanadan, V.P., "Malignancy-related Cell Surface Mucin-Type Glycoproteins", 1988, Indian J. of Biochem. & Biophys., vol. 25, pp. 36-42.
Carraway, K.L., et al., "Structural and Functional Aspects of Tumor Cell Sialomucins", 1986, Molecular and Cell. Biochem., vol. 72, pp. 109-120.
Clausen, H., et al., "ABH and Related Histo-Blood Group Antigens; Immunochemical differences in Carrier Isotypes and Thier Distribution", 1989, VOX Sanguinis, Int'l J. Transfusions, vol. 56, pp. 1-20.
Clausen, H., et al., "Monoclonal Antibodies directed to the Blood Group A Associated Structure, Galactosyl-A: Specificity and Relation to the Thomsen-Friedenrich Antigen", 1988, Molec. Immunol., vol. 25, pp. 199-204.
Codington, J.F., et al., "Glycoprotein Coat of the TA3 Cell. Isolation and Partial Characterization of a Sialic Acid Containing Glycoprotein Fraction", 1972, Biochemistry, vol. 11, pp. 2559-2564.
Codington, J.F., et al., "Epiglycanin-A Carcinoma-Specific Mucin-Type Glycoprotein of the Mouse TA3 Tumour", 1992, Glycobiology, vol. 2, pp. 173-180.
Codington, J.F., et al., "Antibody to Epiglycanin and Radioimmunoassay to Detect Epiglycanin-Related Glycoproteins in Body Fluids of Cancer Patients", 1984, J. Nat'l Cancer Inst., vol. 75, pp. 1029-1038.
Codington, J.F., et al., "Isolation and Partial Characterization of an Epiglycanin-Like Glycoprotein From a New Non-Strain-Specific Subline of TA3 Murine Mammary Adenocarcinoma", 1979, J. Nat'l. Cancer Inst., vol. 63 pp. 153-160.
Codington, J.F., et al., "Evidence that the Major Cell Surface Glycoprotein of the TA3-Ha Carcinoma Contains the Vicia Graminea Receptor", 1975, Biochemistry, vol. 14, pp. 855-859.
Codington, J.F., et al., "Cell-Surface Glycoproteins of Two Sublines of the TA3 Tumor", 1973 J. Nat'l. Cancer Insitute, vol. 51, pp. 585-591.
Dodd, J., et al., "The Value of the Monoclonal Antibody (Cancer Antigen 125) in Serial Monitoring of Ovarian Cancer: a Comparison with Circulating Immune Complexes", 1985, Brit. J. Obstetrics and Gynaecology, vol. 92, pp. 1054-1060.
Haavik, S., et al., "Development and Characterization of Monoclonal Antibodies Against a Mucin-Type Glycoprotein", 1992 Glycobiology, vol. 2, pp. 217-224.
Hanisch, F.G., et al., "Structural Studies on Oncofetal Carbohydrate Antigens (CA 19-9, CA 50, and CA 125) Carried By O-Linked Sialyloligosaccharides on Human Amniotic Mucins", 1988, Carbohydr. Res., vol. 178, pp. 29-47.
Henningsson, C.M., et al., "T Cell Recognition of a Tumor-Associated Glycoprotein and its Synthetic Carbo-hydrate Epitopes: Stimulation of Anticancer T Cell Immunity In Vivo", 1987, Cancer Immunol. Immunother, vol. 25, pp. 231-241.
Hilkens, J., "Biochemistry and Function of Mucins in Malignant Disease", 1988, Cancer Rev., vol. 11-12, pp. 25-54.
Hinoda, Y., "Immunochemical Characterization of Adenocarcinoma-Associated Antigen YH206", Int'l J. Cancer, vol. 42, pp. 653-658.
Ishida, M., et al., "Related Glycoproteins from Normal Secretary and Malignant Breast Cells", 1989, Tumor Biol., vol. 10, pp. 12-22.
Kjelden, et al., "Preparation and Characterization of Monoclonal Antibodies Directed to the Tumor-Associated O-linked Sialosyl-2.fwdarw.6 .alpha.-N-Acetylgalactosaminyl (Sialosyl-Tn) Epitope", 1988, Cancer Research vol. 48, pp. 2214-2220.
Laemmli, U.K., "Cleavage of Structural Proteins During the Assembly of the Head of Bacteriophage T4", 1970, vol. 227, pp. 680-685.
Lan, M.S., et al., "Cloning and Sequencing of a Human Pancreatic Tumor Mucin cDNA", 1990, J. Biological Chem., vol. 265, pp. 15294-15299.
Lan, M.S., et al., "Isolation and Properties of a Human Pancreatic Adenocarcinoma-associated Antigen, DU-PAN-2", 1985, vol. 45, pp. 305-310.
Leiter, J., et al., "Cancer Chemotherapy Screening Data XXXIII", 1965, Cancer Research Supp., vol. 25, pp. 11-12.
Marsella, R.C., et al., "Identification of Adenocarcinoma in Effusions: A Comparison of Immunoperoxidase Staining for Monoclonal Antibody B72.3 and Carcinoembryonic Antigen", Acta Cytologica, vol. 34, pp. 578-580.
Marx, J.L., "Cancer Vaccines Show Promise at Last", 1989, Science Res. News, vol. 245, pp. 813-815.
Richardson, G., et al., "KLE: A Cell Line with Defective Estrogen Receptor Derived From Undifferntiated Endometrial Cancer", 1984, Gyneocologic Oncology, vol. 17, pp. 213-230.
Sheer, D.G., et al., "Purification and Composition of the Human Tumor-associated Glycoprotein (TAG-72) Defined by Monoclonal Antibodies CC49 and B72.3", 1988, Cancer Research, vol. 48, pp. 6811-6818.
Slayter, H.S., et al., "Configuration of Glycoprotein Fragments Cleaved from Tumor Cells by Proteolysis", 1973, J. Biological Chem., No. 10, pp. 3405-3410.
Spicer, A.P., et al., "Molecular Cloning and Analysis of the mouse Homologue of the Tumor-Associated Mucin, MUC1, Reveals Conservation of Potential O-Glycosylation Sites, Transembrane, and Cytoplasmic Domains and a Loss of Minisatellite-like Polymorphism", 1991, J. Biological Chem., vol. 266, pp. 15099-15109.
Springer, G.F., et al., "Blood Group Tn-Active Macromolecules from Human Carcinomas and Erythrocytes: Characterization of and Specific Reactivity with Mono--and Poly-clonal Anti-Tn Antibodies Induced by Various Immunogens", 1988, Carbohydrate Research, vol. 178, pp. 271-292.
Tjandra, J.J., et al., "Application of Mammory Serum Antigen Assay in the Management of Breast Cancer: A Preliminary Report", 1988, British J. Surg., vol. 75, pp. 811-817.
Van den Eijnden, et al., "Chemical Structure of Epiglycanin, the Major Glycoprotein of the TA3-Ha Ascites Cell", 1979, J. Biological Chem., vol. 254, pp. 1215
Codington John F.
Haavik Svein
Epigen, Inc.
Scheiner Toni R.
LandOfFree
Antibodies to human carcinoma antigen does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies to human carcinoma antigen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies to human carcinoma antigen will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-802637