Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-11-21
2006-11-21
Kemmerer, Elizabeth (Department: 1649)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S350000, C530S351000, C435S007210, C435S069100, C435S069500, C435S326000, C435S335000, C424S130100, C424S143100, C436S501000, C536S023100
Reexamination Certificate
active
07138500
ABSTRACT:
Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and host cells transformed with the recombinant expression vectors are disclosed, along with methods for producing the novel polypeptides by cultivating such transformed host cells. Soluble forms of the 4-1BB-L or 4-1BB polypeptides are derived from the extracellular domains thereof.
REFERENCES:
patent: 4675285 (1987-06-01), Clark et al.
patent: 5030576 (1991-07-01), Dull et al.
patent: 5217880 (1993-06-01), Mitta et al.
patent: 5312733 (1994-05-01), MacLeod
patent: 6362325 (2002-03-01), Kwon
patent: 2108401 (1995-03-01), None
patent: WO 95/07984 (1995-03-01), None
Bowie et al., Science 247:1306-1310, 1990.
Wells Biochemistry 29;8509-8517, 1990.
Ngo et al., The Protein Folding Problem and Tertiary Structure, pp. 14-16, 1994.
Pollok et al., J. Immunology 150:771-787, Feb. 1993.
Alderson et al., Eur. J. Immunol. 2219-2227, 1994.
Benjamini ed. Immunology: A Short Course, p. 40, 1988.
Pollok et al. J. Immunol. 150(771-781), Feb. 1, 1993.
Kwon, B. and Weissman, S., “cDNA sequences of two inducible T-cell genes”,Proc. Natl. Acad. Sci. USA, 86:1963-1967, Mar. 1989.
Kwon, B. et al., “Expression Characteristics of Two Potential T Cell Mediator Genes”,Cellular Immunology, 121:414-422, 1989.
Kwon, B. et al., “Isolation and initial characterization of multiple species of T-lymphocyte subset cDNA clones,”Proc. Natl. Acad. Sci.USA, 84: 2896-2900, May 1987.
Pollok, K. et al., “Inducible T Cell Antigen 4-1BB”,The Journal of Immunology, 150:771-781, Feb. 1, 1993.
Mallet, S. and Barclay, A.N., “A new superfamily of cell surface proteins related to the nerve growth factor receptor”,Immunology Today, 12:220-223, 1991.
Schwartz et al., “cDNA Sequence Tissue Distribution and Regulation of Expression of a New Member of the Human TNF-NGF Receptor Family”,Arthritis Rheum.35 (9 Suppl.), Abstract D63, p. S224, 1992.
Schwartz et al., “Identification of a New Member of the Human Nerve Growth Factor/Tumor Necrosis Factor Receptor Family,”J. Immunology 150: 298A, Abstract No. 1705, 1993.
Chalupny, N. et al., “T-cell activation molecule 4-1BB binds to extracellular matrix proteins”,Proc. Natl. Acad. Sci. USA, 89:10360-64, Nov. 1992.
Flanagan, J. and Leder, P., “The kit Ligand: A Cell Surface Molecule Altered in Steel Mutant Fibroblasts”,Cell 63:185-194, Oct. 5, 1990.
Aruffo, A. and Seed, B., “Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system”,Proc. Natl. Acad. Sci. USA 84: 8573-8577, Dec. 1987.
Capon, D., et al., “Designing CD4 immunoadhesins for AIDS therapy”,Nature 337: 525-531, Feb. 9, 1989.
Steele, R.E., “Factor hunting made easier”,TIBS16:125-126, Apr. 1991.
Armitage, R., et al., “Molecular and biological characterization of a murine ligand for CD40”,Nature 357: 80-82 (1992).
Hollenbaugh, D., et al., “The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity”,The Embo Journal 11: 4313-4321 (1992).
Ohtsuka, E., et al., “An Alternative Approach to Deoxyoligonucleotides as Hybridization Probes by Insertion of Neoxyinosine at Ambiguous Codon Positions,”Journal of Biol. Chemistry 260: (5) 2605-2608, 1985.
Frohman, M., et al., “Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer,”Proc. Natl. Acad. Sci. USA, 85:8998-9002, 1998.
Alderson Mark R.
Goodwin Raymond G.
Smith Craig A.
Bellas Christine M.
Brannock Michael
Henry Janis C.
Immunex Corporation
Kemmerer Elizabeth
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