Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-09-12
2006-09-12
Housel, James C. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S005000, C435S339000, C435S389000, C435S387000, C435S389000, C436S501000, C424S137100, C424S147100, C424S149100
Reexamination Certificate
active
07105303
ABSTRACT:
Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the E1 and E2 proteins aggregate into virus-like particles.
REFERENCES:
patent: 5135854 (1992-08-01), MacKay et al.
patent: 5308750 (1994-05-01), Mehta et al.
patent: 5350671 (1994-09-01), Houghton et al.
patent: 6171782 (2001-01-01), Houghton et al.
patent: 0 320 267 (1988-12-01), None
patent: 0 318 216 (1989-05-01), None
patent: 0 318 216 (1989-05-01), None
patent: 0 320 267 (1989-06-01), None
patent: 0 388 232 (1990-09-01), None
patent: 388232 (1990-09-01), None
patent: 0 450 931 (1991-10-01), None
patent: 0 556 292 (1999-12-01), None
patent: WO 91/15771 (1991-10-01), None
patent: WO 92/08734 (1992-05-01), None
Lanford et al., “Analysis of Hepatitis C Virus Capsid, E1, and E2/NS1 Proteins Expressed in Insect Cells,”Virology 197:225-235 (1993).
Spaete et al., “Characterization of the Hepatitis C Virus E2/NS1 Gene Product Expressed in Mammalian Cells,”Virology 188:819-830 (1992).
Goochee et al., “The Oligosaccharides of Glycoproteins . . . ,” Biotechnology 9:1347-1355 (1991).
Huikata et al., “Gene Mapping of the Putative . . . ,” Proc. Natl. Acad. Sci. 88:5547-5551 (1991).
Hodo, “Lectins as Tools for the Purification of Membrane Receptors,” Receptor Purification Procedures (Alan R. Liss, NY) pp 45-60 (1984).
Kukuruzinska et al., “Protein Glycosylation in Yeast,” Ann. Rev. Biochem 56:915-944 (1987).
Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, p 138 (1987).
U.S. Appl. No. 07/504,352 entitled “Combinations of Hepatitis C Virus (HVC) Antigens for Use in Immunoassays for Anti-HVC Antibodies,” filed Apr. 4, 1990 (priority document of EP 0 450 931 A1), 58 pages.
Communication of the European Patent Office in the Opposition to EP 0 556 292 B1, enclosing “Opposition to European Patent No 0 556 292,” dated Oct. 23, 2000, 48 pages.
Letter from Carpmaels & Ransford to the European Patent Office in the Opposition to EP 0 556 292, regarding “Proprietor's Reply to Notice of Opposition,” dated Sep. 10, 2001, 8 pages.
Communication of the European Patent Office in the Opposition to EP 0 556 292 B1, regarding “Preliminary Non-Binding Opinion of Opposition Division,” dated Aug. 1, 2002, 6 pages.
Communication of the European Patent Office in the Opposition to EP 0 556 292 B1, entitled “Summons to Attend Oral Proceedings Pursuant to Rule 71(1) EPC,” dated Jun. 16, 2004, 3 pages.
Communication of the European Patent Office in the Opposition to EP 0 842 947, entitled “Notice of Opposition to a European Patent,” dated Jan. 21, 2005, 17 pages.
Darnell, et al.,Molecular Cell Biology, Scientific Books, Inc., Freeman and Company, 41 Madison Ave., NY (1986), “Protein Glycosylation,” pp. 957-964.
Hijikata, et al., “Gene Mapping of the Putative Structural Region of the Hepatitis C Virus Genome by in vitro Processing Analysis,” Proc. Natl. Acad. Sci. USA (Jul. 1991) 88:5547-5571.
Kukuruzinska, et al., “Protein Glycosylation in Yeast,” Ann. Rev. Biochem. (1987) 56:915-944.
Lok, et al., “Antibody Response to Core, Envelope and Non-structural Hepatitis C Virus Antigens: Comparison of Immunocompetent and Immunosuppressed Patients,” Hepatology 18:497-502.
Rosa, et al., “A Quantitative Test to Estimate Neutralizing Antibodies to the Hepatitis C Virus: Cytofluorimetric Assessment of Envelope Glycoprotein 2 to Target Cells,” Proc. Natl. Acad. Sci. US 93:1759-1763.
Smith, et al., “Synthesis of Proteins and Glycoprotein in Dengue Type 2 Virus-Infected Vero andAedes AlbopictusCells,” J. Gen. Virol. 66:559-571.
Stohlman, et al., “Isolation of the Dengue Virus Envelope Glycoprotein From Membrane of Infected Cells by Concanavalin A Affinity Chromatography,” J. Virology 18:132-140.
Wensvoort, et al., “Immunoaffinity Purification and Characterization of the Envelope Protein of Hog Cholera Virus,” J. Gen. Virology 71:531-540.
Winkler, et al. “Studies on the Glycosylation of Flavivirus E Protein and the Role of Carbohydrate in Antigenic Structure,” Virology 159:237-243.
Berger Kim M.
Choo Qui-Lim
Gervase Barbara A.
Hall John A.
Houghton Michael
Harbin Alisa A.
Hill Myron G.
Housel James C.
Moran Michael J.
Novartis Vaccines and Diagnostics Inc.
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