Antibodies to heparin-binding growth factor (HBGF) polypeptides

Details Antibodies to heparin-binding growth factor (HBGF) polypeptides Antibodies to heparin-binding growth factor (HBGF) polypeptides

2011-03-01

2011-03-01

Spector, Lorraine (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C530S387300, C435S069700, C424S133100, C424S139100, C424S145100

Reexamination Certificate

active

07897732

ABSTRACT:
Substantially pure heparin-binding growth factor polypeptides (HBGFs), nucleic acids encoding the HBGFs and antibodies which bind to the HBGFs of the invention are provided. The HBGF polypeptides are useful in methods for the induction of bone, cartilage and tissue formation, growth and development of the endometrium and in the acceleration of wound healing.

REFERENCES:
patent: 4868113 (1989-09-01), Jaye et al.
patent: 4946778 (1990-08-01), Ladner et al.
patent: 5235042 (1993-08-01), Klagsbrun
patent: 5408040 (1995-04-01), Grotendorst et al.
patent: 5565332 (1996-10-01), Hoogenboom et al.
patent: 5585270 (1996-12-01), Grotendorst et al.
patent: 5607918 (1997-03-01), Eriksson et al.
patent: 5795862 (1998-08-01), Frank et al.
patent: 2004/0092450 (2004-05-01), Grotendorst et al.
patent: WO 92 06705 (1992-04-01), None
patent: WO 96 01896 (1996-01-01), None
patent: WO 96 38168 (1996-12-01), None
R.A. Lerner, “Tapping the immunological repertoire to produce antibodies of predetermined specificity”, Nature 299:592-596, Oct. 14, 1982.
R.A. Lerner, “Antibodies of predetermined specificity in biology and medicine”,inAdvances in Immunology 36:1-44, Academic Press 1984.
M.J> Reddehase et al., “A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes”, Nature 337(6208):651-653, 1989.
Campochiaro et al., “Retinal Pigment Epithelial Cells Produce PDGF-like Proteins and Secrete them into their Media”,Exp. Eye Res., (1989) 49:217-227.
Shimokado et al., “A Significant Part of Macrophage-Derived Growth Factor Consists of at Least Two Forms of PDGF”,Cell, 43:277-286, Nov. 1985.
Matsuoka et al., “Two peptides related to platelet-derived growth factor are present in human wound field”,Proc. Natl. Acad. Sci. USA, vol. 86, pp. 4416-4420, Jun. 1989.
Ryseck et al., “Structure, Mapping and Expression offisp-12, a Growth Factor-inducible Gene Encoding a Secreted Cysteine-rich protein”,Cell, vol. 2, pp. 225-233, May 1991.
European Search Report from WO 1996 38168 A, Publication Date Dec. 17, 2001, G. Grotendorst.
Brigstock et al., “Purification and characterization of heparin-binding growth factors from porcine uterus”, Biochemical Journal, Portland Press, London, GB, vol., 266, No. 1, pp. 273-282, 1990.
Steffen et al., “A novel herparin-binding growth factor in pig uterine secretions”, Molecular Biology of the Cell, vol. 4, No. Suppl., p. 19A, Thirty-third annual meeting of the American Socirty for Cell Biology, New Orleans, Louisiana, USA Dec. 11-15, 1993.
Steffen et al., Characterization of low molecular mass forms of connective tissue growth factor (CTGF) that are biologically active and herparin binding, Molecular Biology of the Cell, vol. 7. p, 52A, 1996.

Affiliated with

Also associated with

Rating

Antibodies to heparin-binding growth factor (HBGF) polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibodies to heparin-binding growth factor (HBGF) polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies to heparin-binding growth factor (HBGF) polypeptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2650786