Antibodies to G protein coupled glutamate receptors

Details Antibodies to G protein coupled glutamate receptors Antibodies to G protein coupled glutamate receptors

1995-06-05

1998-02-24

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

5303879, 53038822, 5303882, 53038885, 5303891, 5303913, C07K 1628, G01N 3353, G01N 33536, C12N 512

Patent

active

057211078

ABSTRACT:
Mammalian G protein coupled glutamate receptors are identified, isolated and purified. The receptors have been cloned, sequenced and expressed by recombinant means. The receptors and antibodies thereby may be used to identify agonists and antagonists of G protein coupled glutamate receptor mediated neuronal excitation, as well as in methods of diagnosis.

REFERENCES:
patent: 4859609 (1989-08-01), Dull et al.
patent: 5385831 (1995-01-01), Mulvihill et al.
Gunderson et al., "Glutamate and Kainate Receptors Induced by Rat Brain Messenger RNA in Xenopus Oocytes," Proc. Royal Soc. London Series B 221:127-143, (1984).
Houamed, et al., "Cloning, Expression, and Gene Structure of a G Protein-Coupled Glutamate Receptor from Rat Brain", Science,252:1318-1321. 1991.
Sladeczek et al., "Glutamate Stimulates Inositol Phosphate Formation in Striatal Neurones," Nature 317:717-719, (1985).
Dascal et al., "Involvement of a GTP-Binding Protein in Mediation of Serotonin and Acetylcholine Responses in Xenopus Oocytes Injected with Rat Brain Messenger RNA," Mol. Brain Res. 1:201-209, (1986).
Verdoorn et al., "Rat Brain N-Methyl-D-Aspartate Receptors Expressed in Xenopus Oocytes,"Science 238:1114-1116. (1987).
Recasens et al., "Characterization of Subtypes of Excitatory Amino Acid Receptors Involved in the Stimulation of Inositol Phosphate Synthesis in Rat Brain Synaptoneurosomes," Eur. J. Pharmacology 141:87-93, (1987).
Sugiyama et al., "A New Type of Glutamate Receptor Linked to Inositol Phospolipid Metabolism," Nature 325:531-533, (1987).
Takahashi et al., "Rat Brain Serotonin Receptors in Xenopus Oocytes are Coupled by Intracellular Calcium to Endogenous Channels," Proc. Natl. Acad. Sci. USA., 84:5063-5067, (1987).
Hirono et al., "Characterization of Glutamate Receptors Induced in Xenopus Oocytes after Injection of Rat Brain mRNA," Neurosci. Res. 6:106-114, (1988).
Verdoorn and Dingledine, "Excitatory Amino Acid Receptors Expressed in Xeonpus Oocytes: Agonist Pharmacology,"0 Mol. Pharmacol. 34: 298-307, (1988).
Snutch, "The Use of Xenopus Oocytes to Probe Synaptic Communication," Trends In Neurosci 6: 250-256, (1988).
Fong et al., "Properties of Two Classes of Rat Brain Acidic Amino Acid Receptors Induced by Distinct mRNA Populations in Xenopus Oocytes," Synapse 2: 657-665, (1988).
Recasens et al., "A New Quisqualate Receptor Subtype (sAA.sub.2) Responsible for the Glutamate-Induced Inositol Phosphate Formation in Rat Brain Synaptoneurosomes," Neurochem. Int. 13: 463-467 (1988).
Oosawa et al., "Rat Brain Glutamate Receptors Activate Chloride Channels in Xenopus Oocytes Coupled by Inositol Trisphosphate and Ca2+," J. Physiol., 408:223-232 (1989).
Horikoshi et al., "Regional Distribution of Metabotropic Glutamate Response in the Rat Brain Using Xenopus Oocytes," Neurosci. Lett. 105: 340-343, (1989).
Hollmann et al., "Cloning by Functional Expression of a Member of the Glutamate Receptor Family," Nature 342: 643-648, (1989).
Sugiyama et al., "Glutamate Receptor Subtypes May be Classified into Two Major Categories: A Study on Xenopus Oocytes Injected with Rat Brain mRNA," Neuron 3:129-132, (1989).
Moriarty and Landau, "Xenopus Oocyte as Model System to Study Receptor Coupling to Phospholipase C," G. Proteins, Academic Press, N.Y., pp. 479-501 (1990).
Sommer et al., "Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS," Science 249:1580-1585, (1990).
Schoepp et al., "Pharmacological and Functional Characteristics of Metabotropic Excitatory Amino Acid Receptors," Trends Pharm. Sci., 11:508-515 (1990).
Masu et al., "Sequence and Expression of a Metabotropic Glutamate Receptor," Nature 349:760-765 (Feb. 28, 1991).
Dictionary of Immunology, Herbert et al., p. 154, Blackwell Sci. Publ., 1985.
Iverson et al., J. Neurochem 63:625-633, 1994.
Tanabe et al, J. Neuron 8:169-179, 1992.
Walter, J. Imm. Methy 88:149-161, 1980.
Gregor et al, EMBO 7:2673-2699, 1988.

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