Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Fused or hybrid cell – per se
Patent
1996-10-28
1999-04-06
Spiegel, Carol A.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Fused or hybrid cell, per se
435 4, 435 79, 435 7021, 435975, 436518, 436547, 436548, 436808, 53038823, 53038885, C07K 1600
Patent
active
058917225
ABSTRACT:
Antibodies having binding affinity for free IGFBP-1, biological compositions including antibodies having binding affinity for free IGFBP-1, kits for detecting free IGFBP-1 using the antibodies, and cell lines for producing the antibodies are provided. Also provided are devices and methods for detecting free IGFBP-1 and a rupture in a fetal membrane based on the presence of amniotic fluid in a vaginal secretion, as indicated by the presence of free IGFBP-1 in the vaginal secretion. The antibodies that are provided may be characterized by their ability to selectively recognize those IGFBP-1 molecules which are free of IGF-1 and IGF-2, i.e., antibodies which have a binding affinity for free IGFBP-1 that is greater than a binding affinity of the antibody to bound IGFBP-1. These antibodies may also be characterized by their competition with IGF-1 and IGF-2 for binding to IGFBP-1.
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Boltovskaya Marina
Fuks Boris
Konstantinov Alexander
Nazimova Svetlana
Starosvetskaya Nelli
California Research LLC
Spiegel Carol A.
Walker William B.
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