Antibodies to epitopes present on membrane-bound but not secrete

Details Antibodies to epitopes present on membrane-bound but not secrete Antibodies to epitopes present on membrane-bound but not secrete

1993-07-20

1994-11-08

Budens, Robert D.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 7021, 4351722, 5303882, 53038873, 5303896, C12N 520, C07K 1528, C07K 1514

Patent

active

053626435

ABSTRACT:
The invention relates to antibodies which immunologically bind epitopes present on B cell-bound but not secreted IgA. This is accomplished by targeting extracellular epitopes on the membrane anchoring peptide of the .alpha. chain which form, entirely or in part, antigenic epitopes unique to membrane-bound but not secreted IgA.

REFERENCES:
patent: 5079344 (1992-01-01), Chang et al.
patent: 5089603 (1992-02-01), Chang et al.
patent: 5091313 (1992-02-01), Chang
patent: 5254671 (1993-10-01), Chang
patent: 5260416 (1993-11-01), Chang
Sitia et al., "Membrane-Bound and Secreted IgA Contain Structurally Different .alpha.-Chains," J. Immunol. 128(2): 712-716, Feb. 1982.

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