Antibodies to dystrophin and uses therefor

Details Antibodies to dystrophin and uses therefor Antibodies to dystrophin and uses therefor

1994-11-21

1996-07-30

Parr, Margaret

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

5303871, 5303882, 5303891, 435 71, 435 72, 435 795, 436 63, 436518, 436811, 514907, G01N 33567, C07K 1618

Patent

active

055410740

ABSTRACT:
The invention relates to a muscular dystrophy (MD) probe comprising a substantially purified single-stranded nucleic acid sequence capable of hybridizing to a region of DNA on a human X chromosome between the deletion break point at Xp21.3 and the translocation break point at X;11. The invention also relates to a 14 kb cDNA corresponding to the complete MD gene and probes produced therefrom useful in genetic methods of diagnosis of MD. Furthermore, the invention relates to the polypeptide, dystrophin, which corresponds to the MD gene product, and antibodies thereto that are useful in a variety of methods for immunodiagnosis of MD.

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