Antibodies to dense microspheres

Details Antibodies to dense microspheres Antibodies to dense microspheres

1990-06-14

1993-07-27

Rosen, Sam

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

4351722, 43524027, 435 7021, 436548, 53038885, 5303891, 530839, C07K 1528

Patent

active

052311708

ABSTRACT:
Dense microspheres can be extracted and purified to substantial homogeneity from mammalian brain tissue, and used in the screening of therapies for potential effectiveness in impeding the formation of amyloid fibrils associated with Alzheimer's disease and other forms of cerebral amyloidosis. Compounds that, at in-tissue concentrations of 10.sup.-5 M or less, inhibit amyloid formation in a test animal injected intracerebrally with dense microspheres are particularly useful in inhibiting treating cerebral amyloidosis. Antibodies to DMS (dense microspheres) are also disclosed.

REFERENCES:
patent: 4540564 (1985-09-01), Bodor
patent: 4699980 (1987-10-01), Goldstein
Arerback et al. "Immunofluorescent Staining of Dense Microspheres in Human Brain" Arch. Pathol. lab Med. vol. 106, Aug. 1982.
Averback et al. "Dense Microspheres in Normal Brain" Acta. Neuropathol (Berl) vol. 61 148-152 1983.
Averback et al. "Unusual Particles in Motor Neurondisease" Arch. Pathol Lab Med. vol. 105 (9) 490-3 Sep. 1981.
Averback et al. Abstract #P41, 0190 P110, #P11 Cand. J. Neurological Sci. pp. 283-284 and 290-291 May, 1982.
Averback et al. Abstract "Population, Distribution, and Growth of Dense Microspheres in the Human" Fed. Proc. vol. 41, Mar., 1982.
Kipps et al. "Schemata for the Prod. of Monoclonal Antibody Producing Hybridomes" Chapter 108 handbook of Exp. Immunology pp. 108.1-108.9 Blackwell Sci. Pub. London, 1967.
Dense Microsphere in Normal Human Brain; Acta Neuropathol. 61:148-152 (1983), p. 4, line 12.
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Averback Immunofluorescent Staining of Dense Microspheres in Human Brain; ARch. Pathol. Lab Med. 106:394-396 (1982).
Averback Ultrastructural Studies of the Origin and Growth of Dense Micro-Spheres in Normal Human Brain; Can. J. Neurological Sci. pp. 290-291 (May, 1982).
Averback Arch. Pathol. lab Med. 105(9):490-493 (1981).
Averback Population, Distribution, and Growth of Dense Microspheres in the Human; Fed. Proc. 41 (Mar., 1982).
Averback Can. J. Neurological Sci. pp. 283-284 (May, 1982).
Averback New Brain Particles and Nervous Disease; Can. J. Neurological Sci. (conf) p. 187 (1981).

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