Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1998-03-11
1999-03-02
Caputa, Anthony C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303879, 4241331, 4241421, C12P 2108
Patent
active
058772901
ABSTRACT:
There is disclosed a human Corpuscles of Stannius, stanniocalcin polypeptide and DNA(RNA) encoding such polypeptide. There is also provided a procedure for producing such polypeptide by recombinant techniques and for producing antibodies and antagonist/inhibitors against such polypeptide. Another aspect of the invention provides a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing therapeutic treatment of disease or the inhibition of such polypeptide for therapeutic treatment of disease.
REFERENCES:
Wagner et al. (1992), Molecular and Cellular Endocrinology 90(1):7-15.
Butkus et al. (1987), Molecular and Cellular Endocrinology 54:123-133.
Wagner et al. (1997), Journal of Bone and Mineral Research 12:165-171.
Haddad et al. (1996), Endocrinology 137:2113-2117.
Olsen et al. (1996) Proc. Natl. Acad. Sci. USA 93:1792-1796.
Lafeber et al. (1988), Gen. Comp. Endocrinol. 69:19-30.
Stern et al. (1991), J. Bone Mineral Res. 6(11):1153-1159.
Wagner et al. (1991), Mol. Cell. Endocrinol. 79:129-138.
Milliken et al. (1990), Gen. Comp. Endocrinol. 77:416-422.
Adams Mark D.
Olsen Henrik S.
Brookes, Esq. A. Anders
Caputa Anthony C.
Gucker Stephen
Human Genome Sciences Inc.
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