Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds antigen or epitope whose amino acid sequence is...
Reexamination Certificate
2011-05-03
2011-05-03
Szperka, Michael (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds antigen or epitope whose amino acid sequence is...
C424S133100, C424S141100, C424S145100, C435S331000, C514S014700, C530S387300, C530S387900, C530S388250
Reexamination Certificate
active
07935341
ABSTRACT:
Disclosed are antibodies and antigen-binding fragments that bind to a complementary peptide having an amino acid sequence that is encoded by the complement of a nucleotide sequence encoding thrombin or a portion thereof. Such antibodies and antigen-binding fragments can be agonists or antagonists of thrombin receptor-mediated events. Also disclosed are methods of using the agonist antibodies and antigen-binding fragments of the invention to activate the non-proteolytically activated thrombin receptor (NPAR) in a subject in need of such treatment. In addition, methods of using the antagonist antibodies and antigen-binding fragments of the invention to inhibit activation of the NPAR in a subject in need of such treatment are disclosed.
REFERENCES:
patent: 5500412 (1996-03-01), Carney et al.
patent: 5693762 (1997-12-01), Queen et al.
patent: 6721663 (2004-04-01), Roberts et al.
patent: 6762166 (2004-07-01), Haddox et al.
patent: WO 03/013569 (2003-02-01), None
patent: WO 03/061690 (2003-07-01), None
patent: WO 2004/014937 (2004-02-01), None
Bergmann, J.S., et al., “Purification and Characterization of the High Affinity Non-Proteolytically Activated (NPAR) Thrombin Receptor,”Molecular Biology of the Cell 13(Suppl.): 290A (2002) (FromAbstracts: 42nd American Society for Cell Biology Annaul Meeting, Abstract No. 1627).
Bergmann, J.S., et al., “Thrombin and Thrombin peptide TP508 (Chrysalin®) Bind to a High Affinity Receptor That Appears to be Larger Than Known Members of the Proteolytically Activated Receptor (PAR) Family,”Molecular Biology of the Cell, 12(Suppl.): 290A, Abstract No. 1811 (2001).
Blalock, J.E., “Genetic origins of protein shape and interaction rules,”Nature Medicine 1(9): 876-878 (1995).
Suttnar, J. et al., “Determination of the Putative Binding Sites for Thrombin Receptor Activating Peptide through a Hydropathic Complementary Approach,”Thrombosis Haemostasis 83(1): 165-170 (2000).
Blalock, J.E., “Complementarity of peptides specified by ‘sense’ and ‘antisense’ strands of DNA,”Tibtech 8: 140-144 (1990).
Bost, K.L., et al., “Similarity between the corticotrophin (ACTH) receptor and a peptide encoded by an RNA that is complementary to ACTH mRNA,”Proc. Natl. Acad. Sci. USA 82:1372-1375 (1985).
Bost, K.L. and Blalock, J.E., “Production of Anti-idotypic Antibodies by Immunization with a Pair of Complementary Peptides,”J. Molecular Recognition 1(4): 179-183 (1989).
Frost, G.H., et al., “Monoclonal Antibody to the Thrombin Receptor Stimulates DNA Synthesis in Combination with Gamma-Thrombin or Phorbol Myristate Acetate,”J. Cell Biology 105(6): 2551-2558 (1987).
Gho, Y.S. and Chae, C-B., “Anti-angiogenin Activity of the Peptides Complementary to the Receptor-binding Site of Angiogenin,”J. Biological Chemistry 272(39): 24294-24299 (1997).
Bergmann John S.
Carney Darrell H.
Fuller Gerald M.
Davis Steven G.
OrthoLogic Corp.
Szperka Michael
LandOfFree
Antibodies to complementary peptides of thrombin or portions... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies to complementary peptides of thrombin or portions..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies to complementary peptides of thrombin or portions... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2664002