Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-05
1999-09-21
Knode, Marian C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303873, 5303882, 53038885, 43524027, C07K 1640, C12N 512
Patent
active
059555831
ABSTRACT:
The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Antibodies to the cGMP-binding, cGMP-stimulated phosphodiesterase are disclosed. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
REFERENCES:
Thomas et al, J. Biol Chem 265: 14971-14978, 1990.
Sarada et al, Archives Biochem Biophys 215:183-198, 1982.
Mumby et al, J. Biol. Chem 257:13283-13290, 1982.
Riechmann et al., Nature 332:323-327, 1988.
Ausubel et al., Current Protocols in Molecular Biology, John Wiley & Sons,
Beavo et al., Cyclic Nucleotide Phosphodiesterases: Structure, Regulation Contents!.
Bradford, "A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding", Anal. Biochem., 72:248-254 (1976).
Charbonneau et al., "Identification of a Noncatalytic cGMP-Binding Domain Conserved in Both the cGMP-Stimulated and Photoreceptor Cyclic Nucleotide Phosphodiesterases", Proc. Natl. Acad. Sci. USA, 87:288-292 (1990).
Charbonneau, "Structure-Function Relationships Among Cyclic Nucleotide Phosphodiesterases", Chapter 11, pp. 267-296 in Beavo et al., Cyclic Nucleotide Phosphodiesterases: Structure, Regulation and Drug Action, John Wiley & Sons, Chichester, UK (1990).
Collins et al., "The Human .beta.-Subunit of Rod Photoreceptor cGMP Phosphodiesterase: Complete Retinal cDNA Sequence and Evidence for Expression in Brain", Genomics, 13:698-704 (1992).
Coquil et al., "Characteristics of a New Binding Protein Distinct From the Kinase for Guanosine 3':5'-Monophosphate in Rat Platelets", Biochim. Biophys. Acta, 631:148-165 (1980).
Coquil et al., "Occurrence of the Methylisobutylxanthine-Stimulated Cyclic GMP Binding Protein in Various Rat Tissues", Biochem. Biophys. Res. Commun., 127:226-231 (1985).
Davis et al., "Purification and Characterization of Guanosine 3':5'-Monophosphate-specific Phosphodiesterase from Guinea Pig Lung", J. Biol. Chem., 252:4078-4084 (1977).
Dayhoff et al., "Establishing Homologies in Protein Sequences", Methods Enzymol., 91:524-545 (1983).
Erickson et al., "Macromolecular X-Ray Crystallography and NMR as Tools for Structure-based Drug Design", Ann. Rep. Med. Chem., 27:271-289 (1992).
Feinberg et al., "A Technique for Radiolabeling DNA Restriction Endonuclease Fragments to High Specific Activity", Anal. Biochem., 137:266-267 (1984).
Feng et al., "Progressive Alignment and Phylogenetic Tree Construction of Protein Sequences", Methods Enzymol., 183:375-387 (1990).
Flockhart et al., "Preparation of the Catalytic Subunit of cAMP-Dependent Protein Kinase", Chapter 12, pp. 209-215 in Marangos et al., Brain Receptor Methodologies, Part A, Academic Press, Orlando, Florida (1984).
Francis et al., "Cyclic GMP-Binding Cyclic GMP-Specific Phosphodiesterase from Lung", Chapter 5, pp. 117-140 in Beavo et al., Cyclic Nucleotide Phosphodiesterases: Structure, Regulation and Drug Action, John Wiley & Sons, Chichester, UK (1990).
Francis et al., "Characterization of a Novel cGMP Binding Protein from Rat Lung", J. Biol. Chem., 255:620-626 (1979).
Francis et al., "Purification of cGMP-Binding Protein Phosphodiesterase from Rat Lung", Methods Enzymol., 159:722-729 (1988).
Francis et al., "Cyclic Nucleotide Phosphodiesterases are Zinc Hydrolases as Indicated by Conserved Zinc-Binding Motifs, Specific Zinc Binding, and Zinc-supported Catalysis", The FASEB J., 8: Abstract 2148 (May 15, 1994).
Hamet et al., "Cyclic GMP Binding and Phosphodiesterase:Implication for Platelet Function", Adv. Cyclic Nucleotide Protein Phosphorylation Res., 16:119-136 (1984).
LeTrong et al., "Amino Acid Sequence of the Cyclic GMP Stimulated Cyclic Nucleotide Phosphodiesterase from Bovine Heart", Biochemistry, 29:10280-10288 (1990).
Li et al., "Bovine Cone Photoreceptor cGMP Phosphodiesterase Structure Deducted from A cDNA Clone", Proc. Natl. Acad. Sci. USA, 87:293-297 (1990).
Lipkin et al., ".beta.-Subunit of Bovine Rod Photoreceptor cGMP Phosphodiesterase", J. Biol. Chem., 265:12955-12959 (1990).
Martins et al., "Purification and Characterization of a Cyclic GMP-Stimulated Cyclic Nucleotide Phosphodiesterase from Bovine Tissues", J. Biol. Chem., 257:1973-1979 (1982).
Matsudaira, "Sequence from Picomole Quantities of Proteins Electroblotted Onto Polyvinylidene Difluoride Membranes", J. Biol. Chem., 262:10035-10038 (1987).
McAllister-Lucas et al., "Mutagenesis of a Lung cGMP-Specific Phosphodiesterase Provides Evidence for Two Distinct sites for Allosteric cGMP-Binding, with an essential Aspartic Acid at Each Site", The FASEB J., Abstract 2149 (Mar. 15, 1994).
Murray et al., "Inhibitors of Cyclic Nucleotide Phosphodiesterases as Therapeutic Agents", Biochem. Soc. Trans., 20(2):460-464 (1992).
Oskenberg et al., "A Single Amino-Acid Difference Confers Major Pharmacological Variation Between Human and Rodent 5-HT.sub.1B Receptors", Nature, 360:161-163 (1992).
Ovchinnikov et al., "Cyclic GMP Phosphodiesterase from Cattle Retina", FEBS Lett., 204:288-292 (1986).
Ovchinnikov et al., "Cyclic GMP Phosphodiesterase From Bovine Retina", FEBS Lett., 223:169-173 (1987).
Price et al., "Expression of Heterologous Protiens in Saccharomyces cerevisiae Using the ADH2 Promoter", Meth Enzymol., 185: 308-318 (1990).
Prpic et al., "Separation and Assay of Phosphodiesterase Isoforms in Murine Peritoneal Macrophages Using Membrane Matrix DEAE Chromatography and
Reeves et al., Cardiac Phosphodiesterases and the Functional Effects of Selective Inhibition, Chapter 12, pp. 300-316 in Beavo et al., Cyclic Nucleotide Phosphodiesterases: Structure, Regulation and Drug Action, John Wiley & Sons, Chichester, UK (1990).
Sonnenburg et al., "Molecular Cloning of a Cyclic GMP-Stimulated Cyclic Nucleotide Phosphodiesterase cDNA", J. Biol. Chem., 266:17655-17661 (1991).
Thomas et al., "Substrate- and Kinase-directed Regulation of Phosphorylation of a cGMP-binding Phosphodiesterase by cGMP", J. Biol. Chem., 265:14971-14978 (1990).
Thomas et al., "Characterization of a Purified Bovine Lung cGMP-Binding cGMP Phosphodiesterase", J. Biol. Chem., 265:14964-14970 (1990).
Valle and Auld. "Zinc Coordination, Function, and Structure of ZInc Enzymes and Other Proteins", Biochem., 29: 5647-5659 (1990).
Wilbur et al., "Rapid Similarity Searches of Nucleic Acid and Protein Data Banks", Proc. Natl. Acad. Sci. USA, 80:726-730 (1983).
Beavo Joseph A.
Corbin Jackie D.
Ferguson Kenneth M.
Francis Sharron H.
Kadlecek Ann
Board of Regents of the University of Washington
ICOS Corporation
Johnson Nancy A.
Knode Marian C.
Vanderbilt University
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